CAROTENOIDS, THEIR STRUCTURE, PROPERTIES AND BIOLOGICAL ACTION
DOI: http://dx.doi.org/10.30970/sbi.0402.127
Abstract
Dependence of antioxidant properties upon structural features of carotenoids and structure of carotenoids itself are reviewed in this paper. Literature data concerning assimilation and accumulation of these substances in cell generalized in the article. Some aspects of biological effect of carotenoids are discussed as well. It has been shown that anticancerous activity of these substances is caused by their influence on free radical reaction, stimulating of immune system, ability to regulate intercellular connections and to induce apoptosis in malignisated cells.
Keywords
carotenoids, antioxidants, anticancer activity
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1. Бриттон Г. Биохимия природных пигментов. М.: Мир, 1986. 121 с. | ||||
2. Влізло В.В., Куртяк Б.М., Янович В.Г. та ін. Біохімічні основи нормування вітамінного живлення корів. 1. Жиророзчинні вітаміни. Біол. тварин, 2007; 7(1-2): 25-42. | ||||
3. Капитoнов А.Б. Каротиноиды как антиоксидантные модуляторы клеточного метаболизма. Усп. совр. биол, 1996; 116 (2): 179-193. | ||||
4. Капитонов А.Б., Пименов А.М., Обухова Л.К. и др. Радиозащитная эффективность ликопина. Радиационная биол. Радиоэкология, 1994; 34 (3): 67. | ||||
5. Колісник М.І., Борецька Н.І., Камінська М.В. Вплив біомаси каротиносинтезуючих дріжджів Phaffia rhodozyma на стан антиоксидантної системи печінки при інтоксикації щурів тетрахлоретаном. Мед. хімія, 2007; 9 (3): 37-40. | ||||
6. Колісник М.І., Борецька Н.І., Сологуб Л.І. Стан вільнорадикального окиснення і антиоксидантної системи захисту у щурів при згодовуванні дріжджів Phaffia rhodozyma. Біол. тварин, 2007; 9 (1-2): 203-207. | ||||
7. Куртяк Б.М., Янович В.Г. Жиророзчинні вітаміни у ветеринарній медицині і тваринництві. Львів: Тріада плюс, 2004. 426 с. | ||||
8. Ладыгин В.Г., Гордеева С.В. Состав и спектральные свойства пигмент-белковых комплексов фотосистем І и ІІ в клетках мутанта С-41 Chlamydomonas reinhardtii, не содержащего α-каротиноидов. Вестн. Башкир. ун-та, 2001; 2: 53-56. | ||||
9. Ляхович В.В., Вавилин В.А., Зенков Н.К. Активная защита при окислительном стрессе. Антиоксидант-респонсивный элемент. Биохимия, 2006; 71 (9): 1183-1197. | ||||
10. Поляков Н.Э., Лешина Т.В. Некоторые аспекты реакционной способности каротиноидов. Окислительно-восстановительные процессы и комплексообразование. Успехи химии, 2006; 75(12): 1175-1192. | ||||
11. Сімонова М.І., Борецька Н.І., Камінська М.В. та ін. Дія β-каротину та каротинсинтезуючих дріжджів Рhaffia rhodozyma на оксидативний стрес у щурів, інтоксикованих тетрахлоретаном. Укр. біохім. журн, 2010; 82 (3): 6-13. | ||||
12. Четыркин С.В. Транспорт и метаболизм витамина А. Укр. біохім. журн, 2000; 72. (3): 12-24. | ||||
13. Четыркин С.В., Чернухина Л.А, Донченко Г.В. Транспорт ретинола в клеточное ядро іn vitro. Укр. биохим. журн, 1998; 70(2): 17-21. | ||||
14. Шашкина М.Я., Шашкин П.Н., Сергеев А.В. Биодоступность каротиноидов. Вопросы мед. химии, 1999; 45(2): http://medi.ru/pbmc/88902.htm | ||||
15. Abdel-Fatth G., Watzl B., Huang D. еt al. Carotene in vitro stimulates tumour necrosis factor alpha and interleukin I alpha secretion by human pheripheral blood. Pergamon Press, 1993; 13(8): 863-871. https://doi.org/10.1016/S0271-5317(05)80589-5 | ||||
16. Bairati I., Meyer F., Gelinas M. et al. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. J. Clin. Oncol, 2005; 23: 5805-5813. https://doi.org/10.1200/JCO.2005.05.514 PMid:16027437 | ||||
17. Beom V., Bitsch R. Intestinal absorption of lycopene from different matrices and interactions to other carotenoids, the lipid status, and the antioxidant capacity of human plasma. Eur. J. Nutr, 1999; 69(3): 118-125. https://doi.org/10.1007/s003940050052 | ||||
18. Bertram J.S. Induction of connexin 43 by carotenoids: functional consequences. Arch. Biochem. Biophys, 2004; 430(1): 120-126. https://doi.org/10.1016/j.abb.2004.02.037 PMid:15325919 | ||||
19. Bertram S.J., Pung A., Churley M. et al. Diverse carotenoids protect against chemically induced neoplastic transformation. Carcinogenesis, 1991; 12(4): 671-678. https://doi.org/10.1093/carcin/12.4.671 PMid:2013131 | ||||
20. Bhosale P., Larson A. J., Frederick J. M. еt al. Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye. J. Biol. Chem, 2004; 279(47): 49447-49454. https://doi.org/10.1074/jbc.M405334200 PMid:15355982 | ||||
21. Bianchi L., Tateo F., Pizzala R. Carotenoids reduce the chromosomal damage induced by bleomycin in human cultured lymphocytes. Anticancer Res, 1993; 13(4): 1007-1010. | ||||
22. Blumberg J., Block G. The a-Tocopherol, β-Carotene Cancer Prevention Study in Finland. Nutr. Rev, 1994; 52(7): 242-245. https://doi.org/10.1111/j.1753-4887.1994.tb01430.x PMid:8090376 | ||||
23. Burton G.W. Antioxidant action of carotenoids. J. Nutr, 1989; 119(1): 109-111. https://doi.org/10.1093/jn/119.1.109 PMid:2643692 | ||||
24. Burton G.W., Ingold K. U. β-Carotene: an usual type of lipid antioxidant. Science, 1984; 244: 569-573. https://doi.org/10.1126/science.6710156 PMid:6710156 | ||||
25. Chew B.P., Park J.S. Carotenoid action on the immune response. J. Nutr, 2004; 134(1): 257S-261S. https://doi.org/10.1093/jn/134.1.257S PMid:14704330 | ||||
26. Chew B.P., Park J.S., Wong M.W. еt al. A comparison of the anticancer activities of dietary β-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res, 1999; 19(3a): 1849-1854. | ||||
27. Clinton S.K., Emenhiser C., Schwartz S. J. еt al. Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol. Biomarkers Prev., 1996; 5(10): 823-833. | ||||
28. Conklin K.A. Dietary Antioxidants During Cancer Chemotherapy: Impact on Chemotherapeutic Effectiveness and Development of Side Effects. Nutr. and Cancer, 2000; 37 (1): 1-18. https://doi.org/10.1207/S15327914NC3701_1 PMid:10965514 | ||||
29. Conn P.F., Schalch W., Truscott T.G. The singlet oxygen and carotenoid interaction. J. Photochem. Photobiol. B: Biol, 1991; 11(1): 41-47. https://doi.org/10.1016/1011-1344(91)80266-K | ||||
30. Crews H., Alink G., Andersen R. A critical assessment of some biomarker approaches linked with dietary intake. Br. J. Nutr, 2001; 86(1): 5-35. https://doi.org/10.1079/BJN2001337 PMid:11520422 | ||||
31. Cunningham F.X., Gantt E. Genes and enzymes of carotenoid biosynthesis in plants. Annu. Rev. Plant Pysiol. Plant Mol. Biol, 1998. 49: 557-583. https://doi.org/10.1146/annurev.arplant.49.1.557 PMid:15012246 | ||||
32. El-Agamey A., Lowe G.M., McGarvey D.J. еt al. Carotenoid radical chemistry and antioxidant/pro-oxidant properties. Arch. Biochem. Biophys, 2004; 430(1): 37-38. https://doi.org/10.1016/j.abb.2004.03.007 PMid:15325910 | ||||
33. Ferreira A.L., Yeum K.J., Russell R.M. et al. Enzymatic and oxidative metabolites of lycopene. J. Nutr. Biochem, 2004: 15(8): 493-502. https://doi.org/10.1016/j.jnutbio.2004.02.007 | ||||
34. Flagg E.W., Coates R.J., Greenberg R.S. Epidemiologic studies of antioxidants and cancer in humans. J. Am. Coll. Nutr, 1995; 14(5): 419-427. https://doi.org/10.1080/07315724.1995.10718532 PMid:8522720 | ||||
35. Furr H.C., Clark R.M. Intestinal absorption and tissue distribution of carotenoids. Nutr. Biochem, 1997; 8(5): 364-377. https://doi.org/10.1016/S0955-2863(97)00060-0 | ||||
36. Gerster H. Review: antioxidant protection of the ageing macula. Age Ageing, 1991; 20(1): 60-69. https://doi.org/10.1093/ageing/20.1.60 PMid:2028852 | ||||
37. Gradelet S., Astorg P., Leclerc J. et al. Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobioticmetabolizing enzymes in the rat. Xenobiotica, 1996; 26 (1): 49-63. https://doi.org/10.3109/00498259609046688 PMid:8851821 | ||||
38. Gross M.D., Snowdon A.D. Plasma lycopene and longevity: Findings from the Nun Study. FASEB J, 2001; 15(4): 400. | ||||
39. Handelman G.J., Kuijk F.J., Chatterjee A. et al. Characterization of products formed during the autoxidation of β-carotene. Free Rad. Biol. Med, 1991; 10(6): 427-437. https://doi.org/10.1016/0891-5849(91)90051-4 | ||||
40. Hennekens C.H., Buring J.E., Manson J.E. et al. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med, 1996; 334(18): 1145-1149. https://doi.org/10.1056/NEJM199605023341801 PMid:8602179 | ||||
41. Huang D.S., Odeleye O.E., Watson R.R. Inhibitory effects of canthaxanthin on in vitro growth of murine tumour cells. Cancer Lett, 1992; 65 (3): 209-213. https://doi.org/10.1016/0304-3835(92)90233-L | ||||
42. Huang M.E., Ye Y., Chen S.R. et al. Use of all-trans-retinoic acid in treatment of acute promyelocytic leukemia. Blood, 1988; 72(2): 267-272. | ||||
43. Jewell C., O'Brien N. Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br. J. Nutr, 1999; 81(3): 235-242. https://doi.org/10.1017/S0007114599000434 | ||||
44. Jezowska I., Wolak A., Gruszecki W. et al. Effect of β-carotene on structural and dynamic properties of model phosphatidylcholine membranes. II. A 31P-NMR and 13C-NMR study. Biochim. Biophys. Acta, 1994; 1194 (1): 143-148. https://doi.org/10.1016/0005-2736(94)90213-5 | ||||
45. Jyonouchi H., Hill R.J., Tomita Y. et al. Studies of immunomodulating actions of carotenoids. I. Effects of β-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system. Nutr. Cancer, 1991; 16(1): 93-105. https://doi.org/10.1080/01635589109514148 PMid:1796012 | ||||
46. Jyonouchi H., Sun S., Iijima K. et al. Antitumor activity of astaxanthin and its mode of action. Nutr. Cancer, 2000; 36(1): 59-65. https://doi.org/10.1207/S15327914NC3601_9 PMid:10798217 | ||||
47. Jyonouchi H., Zhang L., Gross M. et al. Immunomodulating actions of carotenoids: Enhancement of in vivo and in vitro antibody production to Tdependent antigens. Nutr. Cancer, 1994; 21(1): 47-58. https://doi.org/10.1080/01635589409514303 PMid:8183722 | ||||
48. Kennedy T.A., Liebler D.C. Peroxyl radical oxidation of β-carotene: formation of β-carotene epoxides. Chem. Res. Toxicol, 1991; 4(1): 290-295. https://doi.org/10.1021/tx00021a005 PMid:1912311 | ||||
49. Khachik F., Spangler C.J., Smith J.C. et al. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem, 1997; 69(9): 1873-1881. https://doi.org/10.1021/ac961085i PMid:9164160 | ||||
50. Kowluru R.A., Menon N.B., Gierhart D.L. Beneficial Effect of Zeaxanthin on Retinal Metabolic Abnormalities in Diabetic Rats. Investigative Ophthalmology and Visual Science, 2008; 49 (4): 1645-1651. https://doi.org/10.1167/iovs.07-0764 PMid:18385086 | ||||
51. Krinsky N.I. Actions of carotenoids in biological systems. Ann. Rev. Nutr, 1993; 13: 561-587. https://doi.org/10.1146/annurev.nu.13.070193.003021 PMid:8369159 | ||||
52. Krinsky N.I., Johnson E.J. Carotenoid actions and their relation to health and disease. Mol. Aspects Med, 2005; 26(6): 459-516. https://doi.org/10.1016/j.mam.2005.10.001 PMid:16309738 | ||||
53. Krutovskikh V., Asamoto M., Takasuka N. et al. Differential dose-dependent effects of alpha-, β-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo. Jpn. J. Cancer Res, 1997; 88(12): 1121-1124. https://doi.org/10.1111/j.1349-7006.1997.tb00338.x PMid:9473727 PMCid:PMC5921344 | ||||
54. Kunisada M., Budiyanto A., Bito T. et al. Retinoic acid suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma. Br. J. Dermatol, 2005; 152(3): 435-443. https://doi.org/10.1111/j.1365-2133.2005.06471x PMid:15787811 | ||||
55. Kurashige M., Okimasu E., Inoue M. et al. Inhibition of oxidative injury of biological membranes by astaxanthin. Physiol. Chem. Phys. Med, 1990; 22(1): 27-38. | ||||
56. Lee J., Jiang S., Levine N. et al. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc. Soc. Exp. Biol. and Med, 2000; 223(2): 170-174. https://doi.org/10.1046/j.1525-1373.2000.22323.x PMid:10654620 | ||||
57. Levin A.A. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa. Nature, 1992; 355: 359. https://doi.org/10.1038/355359a0 PMid:1309942 | ||||
58. Liebler D.C., McClure T.D. Antioxidant reactions of β-carotene: Identification of carotenoid-radical adducts. Chem. Res. Toxicol, 1996: 9(1): 8-11. https://doi.org/10.1021/tx950151t PMid:8924620 | ||||
59. Mangelsdorf D.J., Thummel C., Beato M. et al. The nuclear receptor superfamily: the second decade. Cell, 1995: 83(6): 835-839. https://doi.org/10.1016/0092-8674(95)90199-X | ||||
60. Martin H.D., Ruck C., Schmidt M. Chemistry of carotenoid oxidation and free radical reactions. Pure Appl. Chem, 1999; 71(12): 2253-2262. https://doi.org/10.1351/pac199971122253 | ||||
61. Mattel M.G., Petkovich M., Mattel J.F. et al. Mapping of the human retinoic acid receptor to the q21 band of chromosome 17. Hum. Genet, 1988; 80: 186-188. https://doi.org/10.1007/BF00702866 PMid:2844649 | ||||
62. McDevitt T.M., Tchao R., Harrison E.H. et al. Carotenoids normally present in serum inhibit proliferation and induce differentiation of a human monocyte/macrophage cell line (U937). J. Nutr, 2005; 135(2): 160-164. https://doi.org/10.1093/jn/135.2.160 PMid:15671207 | ||||
63. McNulty H.P., Byun J., Lockwood S.F. et al. Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis. Biochim. Biophys. Acta, 2007; 1768(1): 167-174. https://doi.org/10.1016/j.bbamem.2006.09.010 PMid:17070769 | ||||
64. Miki W. Biological function and activities of animal carotenoids. Pure Appl. Chem, 1991; 63(1): 141-146. https://doi.org/10.1351/pac199163010141 | ||||
65. Moss R.W. Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants? Integrative Cancer Therapies, 2006; 5(1): 63-82. https://doi.org/10.1177/1534735405285882 PMid:16484715 | ||||
66. Nagao A. Oxidative Conversion of Carotenoids to Retinoids and Other Products. J. Nutr, 2004; 134(1): 237S-240S. https://doi.org/10.1093/jn/134.1.237S PMid:14704326 | ||||
67. Naguib M.A. Antioxidant activities of astaxanthin and related carotenoids. J. Agric. Food Chem, 2000; 48(4): 1150-1154. https://doi.org/10.1021/jf991106k PMid:10775364 | ||||
68. Nara E., Hayashi H., Kotake M. et al. Acyclic carotenoids and their oxidation mixture inhibit the growth of HL-60 human promyelocytic leukemia cells. Nutr. Cancer, 2001; 39(4): 273-283. https://doi.org/10.1207/S15327914nc392_18 PMid:11759292 | ||||
69. O'Connor N., O'Brien I. Modulation of UVA light-induced oxidative stress by β-carotene, lutein and astaxanthin in cultured fibroblasts. J. Dermatol. Sci, 1998; 16: 226-230. https://doi.org/10.1016/S0923-1811(97)00058-3 | ||||
70. Obermuller-Jevic U.C., Obermuller-Jevic U.C., Francz P.I. Enhancement of the UVA induction of haem oxygenase-1 expression by β-carotene in human skin fibroblast. FEBS Lett, 1999; 460 (2): 212-216. https://doi.org/10.1016/S0014-5793(99)01342-3 | ||||
71. Olson J.A. Absorption, transport, and metabolism of carotenoids in humans. Pure &Appl. Chem, 1994; 66(5): 1011-1016. https://doi.org/10.1351/pac199466051011 | ||||
72. Olson J.A. Carotenoids, vitamin A and cancer. J. Nutr, 1986; 116(6): 1127-1130. https://doi.org/10.1093/jn/116.6.1127 PMid:3723208 | ||||
73. Omenn G.S., Goodman G.E., Thornquist. D.M. et al. Risk factors for lung cancer and for intervention effects in CARET, the β-Carotene and Retinol Efficacy Trial. J. Natl Cancer Inst, 1996; 88(21): 1550-1559. https://doi.org/10.1093/jnci/88.21.1550 PMid:8901853 | ||||
74. Palozza P. Prooxidant actions of carotenoids in biologic systems. Nutr. Rev, 1998; 56(9): 257-265. https://doi.org/10.1111/j.1753-4887.1998.tb01762.x PMid:9763875 | ||||
75. Palozza P., Krinsky N.I. Antioxidant effects of carotenoids in vitro and in vivo: an overview. Methods Enzymol, 1992; 213: 403-420. https://doi.org/10.1016/0076-6879(92)13142-K | ||||
76. Palozza P., Maggiano N., Calviello G. Canthaxanthin induces apoptosis in human cancer cell lines. Carcinogenesis, 1998; 19(2): 373-376. https://doi.org/10.1093/carcin/19.2.373 PMid:9498292 | ||||
77. Parker R.S. Absorbtion, metabolism, and transport of carotenoids. FASEB J, 1996; 10(5): 542-551. https://doi.org/10.1096/fasebj.10.5.8621054 | ||||
78. Parker R.S. Carotenoids in Human Blood and Tissues. J. Nutr, 1989; 119(1): 101-104. https://doi.org/10.1093/jn/119.1.101 PMid:2643690 | ||||
79. Purev E., Soprano D.R., Soprano K.J. Effect of all-trans retinoic acid on telomerase activity in ovarian cancer cells. J. Exp. Clin. Cancer Res, 2004; 23(2): 309-316. | ||||
80. Rousseau E.J., Davison A.J., Dunn B. Protection by β-carotene and related compounds against oxygen-mediated cytotoxicity and genotoxicity: implications for carcinogenesis and anticarcinogenesis. Free Rad. Biol. Med, 1992; 13(4): 407-433. https://doi.org/10.1016/0891-5849(92)90183-H | ||||
81. Shaish A., Avron М., Ben-Amotz A. Effect of inhibitors on the formation of stereoisomers in the biosinthesis of β-carotene in Dunaliella bardawil. Plant. Cell. Physiol, 1990; 31(5): 689-696. | ||||
82. Stahl W., Nicolai S., Briviba K. et al. Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis, 1997; 18(1): 89-92. https://doi.org/10.1093/carcin/18.1.89 PMid:9054593 | ||||
83. Stahl W., Schwarz W., Sundquist A.R. et al. Cis-trans isomers of lycopene and β-carotene in human serum and tissues. Arch. Biochem. Biophys, 1992; 294(1): 173-177. https://doi.org/10.1016/0003-9861(92)90153-N | ||||
84. Sujak A., Okulski W., Gruszecki W.I. Organisation of xanthophyll pigments lutein and zeaxanthin and in lipid membranes formed with dipalmitoylphosphatidyl-choline. Biochim. Biophys. Acta, 2000; 1509(1): 255-263. https://doi.org/10.1016/S0005-2736(00)00299-6 | ||||
85. Takahashi K., Watanabe M., Takimoto T. et al. Uptake and distribution of astaxanthin in several tissues. and plasma lipoproteins in male broiler chickens fed a yeast (Phaffia rhodozyma) with a high concentration of astaxanthin. Br. Poult. Sci, 2004; 45(1): 133-138. https://doi.org/10.1080/00071660410001668950a PMid:15115211 | ||||
86. Tanaka T., Kawamori T., Ohnishi M. et al. Suppression of azomethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase. Carcinogenesis, 1995; 16(12): 2957-2963. https://doi.org/10.1093/carcin/16.12.2957 PMid:8603470 | ||||
87. Tanaka T., Makita H., Ohnishi M. et al. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin. Cancer Res, 1995; 55(9): 4059-4064. | ||||
88. Tanaka T., Morishita Y., Suzui M. et al. Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. Carcinogenesis, 1994; 15(1): P. 15-19. https://doi.org/10.1093/carcin/15.1.15 PMid:8293542 | ||||
89. Tapiero H., Townsend D. M., Tew K. D. The role of carotenoids in the prevention of human pathologies. Biomed. Pharmacother, 2004; 58(1): 100-110. https://doi.org/10.1016/j.biopha.2003.12.006 PMid:14992791 PMCid:PMC6361147 | ||||
90. Tsuchihashi H., Kigoshi M., Iwatsuku M. et al. Action of β-carotene as an antioxidant against lipid peroxidation. Arch. Biochem. Biophys, 1995; 323(1): 137-147. https://doi.org/10.1006/abbi.1995.0019 PMid:7487059 | ||||
91. Voutilainen S., Nurmi T., Mursu J. et al. Carotenoids and cardiovascular health. Am. J. Clin. Nutr, 2006; 83(6): 1265-1271. https://doi.org/10.1093/ajcn/83.6.1265 PMid:16762935 | ||||
92. Wang J.Y., Wen L.L., Huang Y.N. et al. Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr. Pharm. Des, 2006; 12(27): 3521-3533. https://doi.org/10.2174/138161206778343109 PMid:17017945 | ||||
93. Warner K., Frankel E.N. Effects of β-carotene on light stability of soybean oil. J. Am. Oil Chem. Soc, 1987; 64(3): 213-218. https://doi.org/10.1007/BF02542004 | ||||
94. Wisniewska A., Widomska J., Subczynski W.K. Carotenoid-membrane interactions in liposomes: effect of dipolar, monopolar, and nonpolar carotenoids. Acta biochim. polonica, 2006; 53(3): 475-484. | ||||
95. Wolf G. Retinoids and carotenoids as inhibitors of carcinogenesis and inducers of cell-cell communication. Nutr. Rev, 1992; 50: 270-274. https://doi.org/10.1111/j.1753-4887.1992.tb01345.x PMid:1461590 | ||||
96. Woodall A.A., Britton G., Jackson M.J. Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: relationship between carotenoid structure and protective ability. Biochim. Biophys. Acta, 1997; 1336(6): 575-586. https://doi.org/10.1016/S0304-4165(97)00007-X | ||||
97. Wyss A., Wirtz G.M, Woggon W.D. et al. Expression pattern and localization of β,β-carotene 15,15′-dioxygenase in different tissues. Biochem J, 2001; 354(3): 521-529. https://doi.org/10.1042/bj3540521 PMid:11237856 PMCid:PMC1221683 | ||||
98. Yamauchi R., Miyake N., Inoue H. et al. Products formed by peroxyl radical oxidation of β-carotene. J. Agric. Food Chem, 1993; 41(2): 708-713. https://doi.org/10.1021/jf00029a005 | ||||
99. Yeh S.L., Hu M.L. Induction of oxidative DNA damage in human foreskin fibroblast Hs68 cells by oxidized β-Carotene and lycopene. Free Radic. Res, 2001; 35(2): 203-213. https://doi.org/10.1080/10715760100300751 PMid:11697201 | ||||
100. You C.S., Parker R.S., Goodman K.J. et al. Evidence of cis-trans isomerization of 9-cis-β-carotene during absorption in humans. Am. J. Clin. Nutr, 1996; 64(2): 177-183. https://doi.org/10.1093/ajcn/64.2.177 PMid:8694017 | ||||
101. Zhang L.X., Cooney R.V., Bertram J.S. Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res, 1992; 52(20): 5707-5712. | ||||
102. Zhang P., Omaye S.T. Antioxidant and prooxidant roles for β-carotene, a-tocopherol and ascorbic acid in human lung cells in vitro. Toxicol, 2001; 15 (1): 13-24. https://doi.org/10.1016/S0887-2333(00)00054-0 | ||||
103. Zhang P., Omaye S.T. β-carotene and protein oxidation effect of ascorbic and α-tocopherol. Toxicol, 2000; 146(1): 37-47. https://doi.org/10.1016/S0300-483X(00)00160-8 | ||||
104. Ziegler R.G. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J. Nutr, 1989; 119(1): 116-122. https://doi.org/10.1093/jn/119.1.116 PMid:2643694 |
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