PHYSIOLOGICAL ROLE OF PRIONS IN REGULATION OF Ca 2+ -TRANSPORT AND NEURODEGENERATIVE DISEASES

M. V. Kushkevych; V. V. Vlizlo

doi:10.30970/sbi.0701.274

PHYSIOLOGICAL ROLE OF PRIONS IN REGULATION OF Ca²⁺-TRANSPORT AND NEURODEGENERATIVE DISEASES

M. V. Kushkevych, V. V. Vlizlo

DOI: http://dx.doi.org/10.30970/sbi.0701.274

Abstract

Literature data on the role of physiological prion in Ca²⁺-homeostasis regulation, violation promoting prion-induced neurodegenerations, are summarized. The electrophysiological neuronal disorders and synaptic dysfunction which occur during prion diseases and are accompanied by changes in intracellular ionized Ca²⁺ concentration, are described. Short description of Ca²⁺-transport systems in neurons is presented. Special attention is paid to data obtained in animal models of prion infections and PrP-knocked animals, indicating possible role of PrP^c in the process of Ca²⁺-transport in neurons. In particular, a PrP^c mediated participation in functioning of calcium channels due to binding with NR₂D-subunit of N-methyl-D-aspartate (NMDA)-receptors of Ca²⁺-channels, which provides its neuroprotective role, is described. Also, a PrP^c participation in the synaptic structure formation and neurotransmission is characterized. The interaction of physiological prion with synapsin-1 and synaptophysin that regulates exo-endoendocytosis synaptic vesicles cycle, was studied. The violation of Ca²⁺-homeostasis as one of important factors during prion pathologies is characterised.

Keywords

prion infection, physiological prion, Ca2+-transport systems, synapse

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Biologichni Studii / Studia Biologica