ВПЛИВ МЕЛАТОНІНУ НА СТАН ПРОМІЖНИХ ФІЛАМЕНТІВ ГОЛОВНОГО МОЗКУ ЩУРІВ ЗА УМОВ ГІПЕРТИРЕОЗУ

Анотація

The influence of hyperthyreosis on oxidative stress, state of glial intermediate filaments was investigated. There was observed significant increasing of lipid peroxidation products into both hippocampus and cortex and effect of melatonin. A changes of polypeptide GFAP was observed in hippocampus and cortex. This data shows, that glial cytoskeleton is reconstructed under effects of thyroid hormones. Melatonin as antioxidant are considered as potential protectors in protecting against the development of oxidative stress. Introduction of melatonin reduces the total number GFAP polypeptides and degraded in all investigated brain regions of rats.