FREE RADICALS PROCESS IN BIRD’S LUNG UNDER THE ACTION OF SODIUM HYPOCHLORITE

N. P. Harasym


DOI: http://dx.doi.org/10.30970/sbi.0903.421

Abstract


The effect of sodium hypochlorite that is substance used for the detoxication of organism, and also for plumbing water treatment on content of TBA-active products (secondary lipid peroxidation products) and activity of enzymes of the antioxidant system (АОS) namely superoxide dismutase (SOD), catalase (CAT), glutationperoxydase (GP) in the lung of bird was investigated. It was established that sodium hypochlorite (SН) in concentration 5 µg/l decreased the content of TBA-active products during 14 days in of lung tissues, while SH in concentration 10 µg/l caused the lowering of their content only on 7th day of experiment. After a rehabilitation period, the intensity of processes of lipid peroxidation (LP) increased. It was shown that SH decreased activity of SOD below control values. CAT activity, that destroys H2O2, increased during all experiment under the action of SH in concentration 5 µg/l. Action of SH in 10 µg/l predetermined a decrease of activity CAT on 7th day of experiment and increase – on 20 day of rehabilitation period. On a background of decline of content of secondary lipid peroxidation products the activity of GP increased only on 7th day of action of SH in 5 µg/l concentration in bird’s lung. SH in higher concentration caused a increase in activity of GP both on 14 and on 20 day of experiment.


Keywords


lipid peroxidation, superoxide dismutase, catalase, glutation peroxydase, sodium hypochlorite

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