V. V. Pozur, M. P. Rudyk, T. M. Serhiychuk, V. M. Svyatetska, I. V. Akulenko, D. S. Yankovskyy, G. S. Dyment, T. V. Beregova, L. I. Ostapchenko



Significant decrease in number of members of Lactobacillus genus and the increase in the number of types of aerobic microorganisms E. coli and S. aureus in the faeces and in the biopsy of colonic wall were observed in rats with monosodium glutamate-induced obesity. Treatment with “Symbiter acidophilic” prevented of microbial landscape quantitative changes associated with the obesity. Immunomodulating effect of probiotic was characterized by gender differences in animals with obesity. The treatment with “Symbiter acidophilic” was accompanied by the preclusion of peritoneal phagocyte functional activity disorders and mononuclear phagocytes recruitment to the peritoneal cavity of female rats. Positive changes in the microbiota and immune reactivity in the peritoneal cavity were associated with decreased fat weight of various localizations in female rats who received multiprobiotic. Treatment with “Symbiter acidophilic” was also accompanied by the recruitment of mononuclear cells to the peritoneal cavity in male rats. However, the metabolic profile of these cells was characterized by proinflammatory directedness. The weight index in group of male rats treated with probiotics did not differ from that in the obese male rats.


glutamate obesity, intestinal microflora, probiotics, chronic inflammation, peritoneal macrophages


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