CADMIUM IN HUMAN AND ANIMAL ORGANISM. I. INTAKE AND ACCUMULATION IN CELLS

H. L. Antonyak; L. P. Biletska; N. O. Babych; N. E. Panas; Y. V. Zhylishchych

doi:10.30970/sbi.0402.088

CADMIUM IN HUMAN AND ANIMAL ORGANISM. I. INTAKE AND ACCUMULATION IN CELLS

H. L. Antonyak, L. P. Biletska, N. O. Babych, N. E. Panas, Y. V. Zhylishchych

DOI: http://dx.doi.org/10.30970/sbi.0402.088

Abstract

The article presents analytical review of new data regarding the processes of Cadmium intake in human and animal organisms and accumulation of this heavy metal in organs and tissues. Biochemical mechanisms of Cadmium absorption in digestive tract and respiratory system, Cd²⁺ transport to the cells, interaction with molecules of metallothionein and other proteins are reviewed. Regulation of Cadmium metabolism in animals and human is also considered.

Keywords

Cadmium, heavy metals, organism, membrane transport, accumulation, metallothionein

Full Text:

PDF (Українська)

References

1. Антоняк Г. Л., Сологуб Л. І., Снітинський В. В., Бабич Н. О. Залізо в організмі людини і тварин (біохімічні, імунологічні та екологічні аспекти). Львів, 2006. 310 с.

2. Міщенко В.П., Тимофеєва С.В. Пієлонефрит вагітних при вмісті в крові токсичних металів у допустимих концентраціях і вище. Педиатрия, акушерство и гинекология, 2000; 4: 84-86.

3. Панас Н.Є., Антоняк Г.Л., Снітинський В.В., Кондрацький С. Акумуляція кадмію в органах білих щурів за умов введення CdCl2. Біологія тварин, 2005; 7: 32-35.

4. Панас Н.Є., Жиліщич Ю.В., Білецька Л.П., Антоняк Г.Л. Особливості акумуляції катіонів кадмію і свинцю в органах білих щурів. Науково-технічний бюлетень інституту біології тварин і державного науково-дослідного контрольного інституту ветпрепаратів та кормових добавок, 2007; 8(1, 2): 213-216.

5. Серегин И.В. Фитохелатины и их роль в детоксикации кадмия у высших растений. Успехи биол. химии, 2001; 41: 283-300.

6. Шафран Л.М., Большой Д.В., Пыхтеева Е.Г., Тимофеева С.В. Роль металлотионеинов в биомониторинге загрязнения окружающей среды тяжелыми металлами. Гигиена населенных мест, 2000; 37: 190-193.

7. Andersen O., Nielsen J.B., Sorensen J.A., Scherrebeck L. Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice. Environ. Health Perspect, 1994; 102(3): 199-206. https://doi.org/10.1289/ehp.94102s3199 PMid:7843098 PMCid:PMC1567371

8. Angelova V.R., Ivanova R.V., Todorov J.M., Ivanov K.I. Lead, cadmium, zinc, and copper bioavailability in the soil-plant-animal system in a polluted area. Sci. World J, 2010; 10: 273-285. https://doi.org/10.1100/tsw.2010.33 PMid:20191239 PMCid:PMC5763717

9. ATSDR (Agency for Toxic Substances and Disease Registry). 2007 cercla priority list of hazardous substances that will be the subject of toxicological profiles and support document. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Division of Toxicology (In cooperation with the U.S. Environmental Protection Agency), 2007; 44 p.

10. Beavington F., Cawse P.A., Wakenshaw A. Comparative studies of atmospheric trace elements: improvements in air quality near a copper smelter. Sci. Total Environ, 2004; 332 (1-3): 39-49. https://doi.org/10.1016/j.scitotenv.2004.04.016 PMid:15336889

11. Benedetti J.L., Samuel O., Dewailly E. et al. Levels of cadmium in kidney and liver tissues among a Canadian population (Province of Quebec). J. Toxicol. Environ. Health, 1999; 56: 145-163. https://doi.org/10.1080/009841099158123 PMid:9973001

12. Bernard A. Cadmium and its adverse effects on human health. Indian. J. Med. Res, 2008; 128 (4): 557-564.

13. Beyersmann D., Hechtenberg S. Cadmium, gene regulation, and cellular signaling in mammalian cells. Toxicol. Appl. Pharmacol, 1997; 144: 247-261. https://doi.org/10.1006/taap.1997.8125 PMid:9194408

14. Brancato D.J., Picchioni A.L., Chin L. Cadmium levels in hair and other tissues during continuous cadmium intake. J. Toxicol. Environ. Health, 1976; 2 (2): 351-359. https://doi.org/10.1080/15287397609529438 PMid:1011292

15. Bruwer M., Schmid K.W., Metz K.A., Krieglstein C.F. Increased expression of metallothionein in inflammatory bowel disease. Inflamm. Res., 2001; 50 (60): 289-293. https://doi.org/10.1007/PL00000246 PMid:11475329

16. Brzоska M.M., Moniuszko-Jakoniuk J. Interactions between cadmium and zinc in the organism. Food Chem. Toxicol, 2001; 39: 967-980. https://doi.org/10.1016/S0278-6915(01)00048-5

17. Brzоska M.M., Moniuszko-Jakoniuk J. The influence of calcium content in diet on cumulation and toxicity of cadmium in the organism. Arch. Toxicol, 1998; 72: 63-73. https://doi.org/10.1007/s002040050470

18. Brzoska M.M., Moniuszko-Jakoniuk J., Jurczuk M. et al. Effect of short-term ethanol administration on cadmium retention and bioelement metabolism in rats continuously exposed to cadmium. Alcohol and Alcoholism, 2000; 35 ( 5): 439-445. https://doi.org/10.1093/alcalc/35.5.439 PMid:11022017

19. Bulat Z.P., Djukić-Cosić D., Malicević Z. et al. Zinc or magnesium supplementation modulates Сd intoxication in blood, kidney, spleen, and bone of rabbits. Biol. Trace Elem. Res, 2008; 124 (2): 110-117. https://doi.org/10.1007/s12011-008-8128-5 PMid:18418555

20. Canonne-Hergaux F., Donovan A., Delaby C. et al. Comparative studies of duodenal and macrophage ferroportin proteins. Am. J. Physiol. Gastrointest. Liver Physiol, 2006; 290 (1): 156-G163. https://doi.org/10.1152/ajpgi.00227.2005 PMid:16081760

21. Cannone-Hergaux F., Levy J.E., Fleming M.D. et al. Expression of the DMT1 (Nramp2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood, 2001; 97: 1138-1140. https://doi.org/10.1182/blood.V97.4.1138 PMid:11159549

22. Canpolat E., Lynes M.A. In vivo manipulation of endogenous metallothionein with a monoclonal antibody enhances a T-dependent humoral immune response. Toxicol. Sci, 2001; 62 (1): 61-70. https://doi.org/10.1093/toxsci/62.1.61 PMid:11399794

23. Friberg L., Elinder C.-G., Kjelstrom T., Norberg G.F. (Eds.). Cadmium and Health. A Toxicological and Epidemiological Appraisal. Boca Raton: CRC Press, 1986; 1: 103-178.

24. Godt J., Scheidig F., Grosse-Siestrup C. et al. The toxicity of cadmium and resulting hazards for human health. J. Occup. Med. Toxicol, 2006; 1: 22. https://doi.org/10.1186/1745-6673-1-22 PMid:16961932 PMCid:PMC1578573

25. Goering P.L., Waalkes M.P., Klaassen C.D. et al. Toxicology of cadmium. Biochemical Aspects. Handbook of Experimental Pharmacology. New York: Springer-Verlag, 1995; 115: 189-214. https://doi.org/10.1007/978-3-642-79162-8_9

26. Gundacker C., Pietschnig B., Wittmann K.J. et al. Smoking, cereal consumption, and supplementation affect cadmium content in breast milk. J. Expo. Sci. Environ. Epidemiol, 2007; 17(1): 39-46. https://doi.org/10.1038/sj.jes.7500518 PMid:16955091

27. Hamer D. Metallothionein. Annu. Rev. Biochem, 1986; 55: 913-951. https://doi.org/10.1146/annurev.bi.55.070186.004405 PMid:3527054

28. Hart B.A., Garvey J.S. Detection of metallothionein in bronchoalveolar cells and lavage fluid following repeated cadmium inhalation. Environ. Res, 1986; 40(2): 391-398. https://doi.org/10.1016/S0013-9351(86)80114-1

29. He L., Wang B., Hay E.B., Nebert D.W. Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicol. Appl. Pharmacol, 2009; 238 (3): 250-257. https://doi.org/10.1016/j.taap.2009.02.017 PMid:19265717 PMCid:PMC2789294

30. Hidalgo J., Giralt M., Garvey J.S., Change C.C. Metallothionein in plasma and urine of cadmium workers. Environ. Res, 1982; 28: 179-182. https://doi.org/10.1016/0013-9351(82)90167-0

31. Himeno S., Yanagiya T., Fujishiro H. The role of zinc transporters in cadmium and manganese transport in mammalian cells. Biochimie, 2009; 91(10): 1218-1222. https://doi.org/10.1016/j.biochi.2009.04.002 PMid:19375483

32. Hispard F., de Vaufleury A., Cosson R.P. et al Comparison of transfer and effects of Cd on rats exposed in a short experimental snail-rat food chain or to CdCl2 dosed food. Environ. Int, 2008; 34(3): 381-389. https://doi.org/10.1016/j.envint.2007.09.003 PMid:17961650

33. Honda R., Tawara K., Nishijo M. et al. Cadmium exposure and trace elements in human breast milk. Toxicology, 2003; 186: 255-259. https://doi.org/10.1016/S0300-483X(03)00002-7

34. Hunder G., Javdani J., Elsenhans B., Schumann K. Use of γ-spectrometry for simultaneous determination of 210Pb, 73As, 109Cd, 203Hg and 59Fe distribution and excretion in rats at low doses. Toxicology, 2000; 150: 69-82. https://doi.org/10.1016/S0300-483X(00)00253-5

35. Islam E., Yang X.E., He Z.L., Mahmood Q. Assessing potential dietary toxicity of heavy metals in selected vegetables and food crops. J. Zhejiang. Univ. Sci. B, 2007; 8 (1): 1-13. https://doi.org/10.1631/jzus.2007.B0001 PMid:17173356 PMCid:PMC1764924

36. Jacquillet G., Barbier O., Cougnon M. et al. Zinc protects renal function during cadmium intoxication in the rat. As. J. Physiol. Renal Physiol, 2006; 290 (1): F127-F137. https://doi.org/10.1152/ajprenal.00366.2004 PMid:15942048

37. Jаrup L., Berglund M., Elinder C.G. et al. Health effects of cadmium exposure - a review of literature and a risk estimate. Scand. J. Work Environ. Health, 1998; 24 (11): 1-51.

38. Jin T., Nordberg M., Frech W. et al. Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad). Biometals, 2002; 15: 397-410. https://doi.org/10.1023/A:1020229923095 PMid:12405535

39. Jurczuk M., Brzоska M.M., Rogalska J., Moniuszko-Jakoniuk J. Iron body status of rats chronically exposed to cadmium and ethanol. Alcohol and Alcoholism, 2003, 38(3): 202-207. https://doi.org/10.1093/alcalc/agg057 PMid:12711652

40. Kippler M., Lunnerdal B., Goessler W. et al. Cadmium interacts with the transport of essential micronutrients in the mammary gland - a study in rural Bangladeshi women. Toxicology, 2009; 257(1-2): 64-69. https://doi.org/10.1016/j.tox.2008.12.009 PMid:19126424

41. Kjellstrom T. Exposure and accumulation of cadmium in populations from Japan, the United States, and Sweden. Environ. Health. Perspect, 1979; 28: 169-197. https://doi.org/10.1289/ehp.7928169 PMid:226355 PMCid:PMC1637502

42. Klaassen C.D., Liu J. Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury. Environ. Health. Perspect, 1998; 106 (l): 297-300. https://doi.org/10.1289/ehp.98106s1297 PMid:9539022 PMCid:PMC1533300

43. Klaassen C.D., Liu J., Choudhuri S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol, 1999; 39: 267-294. https://doi.org/10.1146/annurev.pharmtox.39.1.267 PMid:10331085

44. Klaassen C.D., Liu J., Diwan B.A. Metallothionein protection of cadmium toxicity. Toxicol. Appl. Pharmacol, 2009; 238(3): 215-220. https://doi.org/10.1016/j.taap.2009.03.026 PMid:19362100 PMCid:PMC2740813

45. Kostial K. Cadmium. In: Trace Elements in Human and Animal Nutrition. Orlando - San Diego - New York - Austin - London - Montreal - Sydney - Tokyo - Toronto: Acad. Press, Inc., 1986; 2: 319-345. https://doi.org/10.1016/B978-0-08-092469-4.50009-1

46. Leazer T.M., Liu Y., Klaasen C.D. Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicol. Appl. Pharmacol, 2002; 185: 18-24. https://doi.org/10.1006/taap.2002.9505 PMid:12460733

47. Lynes M.A., Borghesi L.A., Youn J., Olson E.A. Immunomodulatory activities of extracellular metallothionein. I. Metallothionein effects on antibody production. Toxicology, 1993; 85(2-3): 161-177. https://doi.org/10.1016/0300-483X(93)90040-Y

48. Mehta A., Flora S.J.S. Possible role of metal distribution, hepatotoxicity and oxidative stress in helating agents induced hepatic and renal metallothionein in rats. Food Chem. Toxicology, 2001; 39: 1029-1038. https://doi.org/10.1016/S0278-6915(01)00046-1

49. Min K.S., Iwata N., Tetsutikawahara N. et al. Effect of hemolytic and iron-deficiency anemia on intestinal absorption and tissue accumulation of cadmium. Toxicol. Lett, 2008; 179 (1): 48-52. https://doi.org/10.1016/j.toxlet.2008.04.001 PMid:18485624

50. Min K.S., Ueda H., Kihara T., Tanaka K. Increased hepatic accumulation of ingested Cd is associated with upregulation of several intestinal transporters in mice fed diets deficient in essential metals. Toxicol. Sci, 2008; 106 (1): 284-289. https://doi.org/10.1093/toxsci/kfn146 PMid:18648087

51. Min K.S., Ueda H., Tanaka K. Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet. Toxicol. Lett, 2008; 176(1): 85-92. https://doi.org/10.1016/j.toxlet.2007.10.011 PMid:18054826

52. Moffatt P., Denizeau F. Metallothinein in physiological and physiopathological processes. Drug Metab. Rev, 1997; 29: 261-307. https://doi.org/10.3109/03602539709037585 PMid:9187522

53. Nordberg M., Nordberg G.F. Toxicological aspects of metallothionein. Cell Mol. Biol, 2000; 46: 451-463.

54. Ohrvik H., Oskarsson A., Lundh T. et al. Impact of iron status on cadmium uptake in suckling piglets. Toxicology, 2007; 240(1-2): 15-24. https://doi.org/10.1016/j.tox.2007.07.012 PMid:17719162

55. Oishi S., Nakagawa J., Ando M. Effects of ingestion of cadmium-polluted rice or low-dose cadmium-supplemented diet on the endogenous metal balance in female rats. Biol. Trace Elem. Res, 2001; 84 (1-3): 155-167. https://doi.org/10.1385/BTER:84:1-3:155

56. Patra R.C., Swarup D., Kumar P. et al. Milk trace elements in lactating cows environmentally exposed to higher level of lead and cadmium around different industrial units. Sci. Total Environ, 2008; 404 (1): 36-43. https://doi.org/10.1016/j.scitotenv.2008.06.010 PMid:18657303

57. Reeves P.G., Chaney R.L. Marginal nutritional status of zinc, iron, and calcium increases cadmium retention in the duodenum and other organs of rats fed rice-based diets. Environ. Res, 2004; 96 (3): 311-322. https://doi.org/10.1016/j.envres.2004.02.013 PMid:15364599

58. Satarug S., Baker J.R., Reilly P.E.B. et al. Cadmium levels in the lung, liver, kidney cortex and urine samples from Australians without occupational exposure to metals. Arch. Environ. Health, 2002; 57: 69-77. https://doi.org/10.1080/00039890209602919 PMid:12071363

59. Satarug S., Baker J.R., Urbenjapol S. et al. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett, 2003; 137: 6-83. https://doi.org/10.1016/S0378-4274(02)00381-8

60. Satarug S., Ujjin P., Vanavanitkun Y. et al. Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai men and women. Toxicol. Lett., 2004; 148: 177-185. https://doi.org/10.1016/j.toxlet.2003.09.015 PMid:15041068

61. Silvera S.A., Rohan T.E. Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control, 2007; 18(1): 7-27. https://doi.org/10.1007/s10552-006-0057-z PMid:17186419

62. Suzuki T., Momoi K., Hosoyamada M. et al. Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo. Toxicol. Appl. Pharmacol, 2008; 227 (3): 462-467. https://doi.org/10.1016/j.taap.2007.10.026 PMid:18076961

63. Tanaka K., Min K., Onosaka S., Fukuhara C. Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice. Experientia, 1987; 52: 525-532. https://doi.org/10.1007/978-3-0348-6784-9_53 PMid:2959544

64. Waalkes M.P. Cadmium carcinogenesis. Mutat. Res, 2003; 533(1): 107-120. https://doi.org/10.1016/j.mrfmmm.2003.07.011 PMid:14643415

65. Wang Y., Wimmer U., Lichtlen P. et al. Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. FASEB J, 2004; 18: 1071-1079. https://doi.org/10.1096/fj.03-1282com PMid:15226267

66. WHO, 1993. Evaluation of Certain Food Additives and Contaminants (Fourty-first Report of the Joint FAO/WHO Expert Committee on Food Additives). WHO Technical Report Series № 837. Geneva: World Health Organization, 1993.

67. Yada S., Arao T., Kawasaki A. et al. Natural cadmium loading and balance in a non-polluted rice paddy field in Japan. Water Sci. Technol, 2008; 58 (11): 2243-2249. https://doi.org/10.2166/wst.2008.571 PMid:19092202

68. Yin X., Knecht D.A. Metallothionein mediates leukocyte chemotaxis. BMC Immunol, 2005; 6: 21. https://doi.org/10.1186/1471-2172-6-21 PMid:16164753 PMCid:PMC1262721

Refbacks

There are currently no refbacks.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Username
Password
Remember me

Biologichni Studii / Studia Biologica

CADMIUM IN HUMAN AND ANIMAL ORGANISM. I. INTAKE AND ACCUMULATION IN CELLS

Abstract

Keywords

Full Text:

References

Refbacks