CHARACTERISTICS OF SODIUM-PROTON ANTIPORTER OF EMBRYO CELLS AND CANCER CELLS
DOI: http://dx.doi.org/10.30970/sbi.0601.186
Abstract
Review presents the structure, regulation, function and biochemical properties on the Na+/H+ exchanger. We cousider factors that influence activation and inhibition of the Na+/H+ exchanger. Review of literature on involving Na+/H+ exchanger in the process of embryonic and tumor cells activation has been carried. Na+/H+ exchanger plays a major role in the pathophysiological processes as hypertension, cancer, tissue or organ hypertrophy. Exchange maintains рНі that for most cells is approximately 7.2, controls cell growth and proliferation, regulates cell volume. Thus, the study of Na+/H+ exchanger of plasma membrane of embryo cell contributes to the understanding of physiological and pathophysiological processes.
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1. Балаболкин М.И., Белоярцева М.Ф. Роль Na+-H+ обменника в патогенезе сахарного диабета 2 типа. Сахарный диабет, 2001; 2: 49-55. | |
| |
2. Aharonovitz O., Kapus A., Szaґszi K. et al. Modulation of Na+/H+ exchange activity by Cl-. Am. J. Physiol. Cell Physiol, 2001; 281: C133-C141. | |
| |
3. Aharonovitz O., Zaun H.C., Balla T. et al. Intracellular pH regulation by Na+/H+ exchange requires phosphatidylinositol 4,5-bisphosphate. J. Cell Biol, 2000; 150: 213-224. | |
| |
4. Aronson P.S., Nee J., Suhm M.A. Modifier role of internal H+ with the Na+/H+ exchanger in renal microvillus membrane vesicles. Nature, 1982; 299: 161-163. | |
| |
5. Aviv A. The link between cytosolic Ca2+ and the Na+/H+ antiport: A unifying factor for essential hypertension. J. Hypertens, 1988; 6: 685-691. | |
| |
6. Aviv A., Livne A. The Na+/H+ antiport, cytosolic free Ca2+, and essential hypertension: A hypothesis. Am. J. Hypertens, 1988; 1: 410-413. | |
| |
7. Barisic K., Karuzic O., Petrik J. et al. Regulation of Na+/H+ exchanger by urogastrone, a potent activator of cell proliferation. Physiol. Res, 2002; 51(5): 483-91. | |
| |
8. Barr K.J., Garrill A., Jones D.H. et al. Contributions of Na+/H+ exchanger isoforms to preimplantation development of the mouse. Mol. Reprod. Dev, 1998; 50(2): 146-53. | |
| |
9. Beltrán A.R., Ramírez M.A., Carraro-Lacroix L.R. et al. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. Pflugers Arch, 2008; 455(5): 799-810. | |
| |
10. Benos D.J. Amiloride: chemistry, kinetics and structure-activity relationships. In Na+/H+ Exchange. Boca Raton: CRC Press, 1988; 121-136. | |
| |
11. Bertrand B., Wakabayashi S., Ikeda T. et al. The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. J. Biol. Chem, 1994; 269(18): 13703-9. | |
| |
12. Bianchini L., Poussǔgur J. Molecular structure and regulation of vertebrate Na+/H+ exchangers. J. Exp. Biol, 1994; 196: 337-45. | |
| |
13. Boyer M.J., Tannock I.F. Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Research, 1992; 52: 4441-4447. | |
| |
14. Busch S., Burckhardt B.C., Siffert W. Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport. Pflugers Arch, 1995; 429(6): 859-69. | |
| |
15. Busch S., Rosskopf D., Lang H.J. et al. Expression, functional characterization and tissue distribution of a Na+/H+ exchanger cloned from Xenopus laevis oocytes (XL-NHE). Pflugers Arch, 1998; 436(6): 828-33. | |
| |
16. Clark J.D., Limbird L.L. Na+/H+ exchanger subtypes, a predictive review. Am. J.Physiol, 1991; 261: G945-G953. | |
| |
17. Counillon L., Pouysseégur J. The Expanding Family of Eucaryotic Na+/H+ Exchangers. J. Biol. Chem, 2000; 275(7): 1-4. | |
| |
18. Demaurex N., Grinstein S. Na+/H+ antiport: modulation by ATP and role in cell volume regulation. J. Exp. Biol, 1994; 196: 389-404. | |
| |
19. Demaurex N., Romanek R.R., Orlowski J. et al. ATP Dependence of Na+/H+ Exchange Nucleotide Specificity and Assessment of the Role of Phospholipids. Physiol, 1997; 109: 117-128. | |
| |
20. Denker S.P., Huang D.C., Orlowski J. et al. Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H+ translocation. Mol. Cell, 2000; 6: 1425-1436. | |
| |
21. Donowitz M., Mohan S., Zhu C. X. et al. NHE3 regulatory complexes. J. Exp. Biol, 2009; 212: 1638-1646. | |
| |
22. Erdogan S., Cetinkaya A., Tuli A. et al. Changes in the activity of defense mechanisms against induced acidosis during meiotic maturation in mouse oocytes. Theriogenology, 2011; 75(6): 1057-66. | |
| |
23. Fafournoux P., Nod J., Pouyssegur J. Evidence that Na+/H+ exchanger isoforms NHEl stable dimers in membranes witah high degree homodimers. J. Biol. Chem, 1994; 269(4): 2589-2596. | |
| |
24. Fine L.G., Nord E.P., Gunther R. et al. Chronic adaptations of Na+/H+ exchange in renal disease. Boca Raton. Fla. CRC Press, 1988; 325-334. | |
| |
25. Gerchman Y., Rimon A., Padan E. A pH-dependent Conformational Change of NhaA Na+/H+ Antiporter of Escherichia coli Involves Loop VIII-IX, Plays a Role in the pH Response of the Protein, and Is Maintained by the Pure Protein in Dodecyl Maltoside. J. Biol. Chem, 1999; 274: 24617-24624. | |
| |
26. Goldman A., Chen H., Khan M.R. et al. The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. PLoS One, 2011; 6(8): 238-235. | |
| |
27. Goss G.G., Jiang L., Vandorpe D.H. et al. Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes. Am. J. Physiol. Cell Physiol, 2001; 281(6): C1978-1990. | |
| |
28. Green J., Muallem S. A common mechanism for activation of the Na/H exchanger by different types of stimuli. FASEBJ, 1989; 3: 2408-2414. | |
| |
29. Harding E.A., Gibb C.A., Johnson M.H. et al. Developmental changes in the management of acid loads during preimplantation mouse development. Biol. Reprod, 2002; 67(5): 1419-1429. | |
| |
30. Hediger M.A., Romero M.F., Peng J.B. et al. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction. Pflugers Arch, 2004; 447(5): 465-468. | |
| |
31. Hove T.M., Van Emous J., Van Echteld C. Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide. Mol. Cell. Biochem, 2003; 250 (1-2): 47-54. | |
| |
32. Inagaki N., Suzuki S., Kuji N. et al. Egg activation induced by osmotic pressure change and the effects of amiloride on the cryopreservation of mouse oocytes. Mol. Hum. Reprod, 1996; 2(11): 835-43. | |
| |
33. Ivanis G., Esbaugh A.J., Perry S.F. Branchial expression and localization of SLC9A2 and SLC9A3 sodium/hydrogen exchangers and their possible role in acid-base regulation in freshwater rainbow trout (Oncorhynchus mykiss). Exp. Biol, 2008; 211(15): 2467-77. | |
| |
34. Jiang L., Chernova M.N., Alper S.L. Secondary regulatory volume increase conferred on Xenopus oocytes by expression of AE2 anion exchanger. Am. J. Physiol. Cell Physiol, 1997; 272: C191-C202. | |
| |
35. Johansson M., Glazier J.D., Sibley C.P. et al. Activity and protein expression of the Na+/H+ exchanger is reduced in syncytiotrophoblast microvillous plasma membranes isolated from preterm intrauterine growth restriction pregnancies. J. Clin. Endocrinol. Metab, 2002; 87(12): 5686-5694. | |
| |
36. Johnstone E.D., Speake P.F., Sibley C.P. Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. Am. J. Physiol. Regul. Integr. Comp. Physiol, 2007; 293(6): R2290-2294. | |
| |
37. Karmazyn M., Gan X.T., A Humphreys R. et al. The Myocardial Na+-H+ Exchange: Structure, Regulation, and Its Role in Heart Disease. Circulation Research, 1999; 85:777-786. | |
| |
38. Kawagishi R., Tahara M., Sawada K. et al. Na+/H+ exchanger-3 is involved in mouse blastocyst formation. J. Exp. Zool. A Comp. Exp. Biol, 2004; 301(9): 767-775. | |
| |
39. Khaled A.R., Moor A.N., Li A. et al. Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol. Cell Biol, 2001; 21(22): 7545-7557. | |
| |
40. Kinsella J.L., Heller P., Froehlich J.P. Na+/H+ exchanger: proton modifier site regulation of activity. Biochem. and Cell Biol, 1998; 76:(5) 743-749. | |
| |
41. Kinsella J. Froehlich J. NHE Proton Modifier Site: Activation and Inactivation Are Controlled by Slow Protein Conformational Changes: INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Dec 7-16th 1998. Canada, 1998. | |
| |
42. Klip A. Action of insulin on Na+/H+ exchange. Boca Raton. Fla. CRC Press, 1988: 285-303. | |
| |
43. Kyte J., Doolittle R.F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol, 1982; 157: 105-132. | |
| |
44. Lane M., Baltz J.M. Bavister B.D. Regulation of intracellular pH in hamster preimplantation embryos by the sodium hydrogen (Na+/H+) antiporter. Biol. Reprod, 1998; 59: 1483-1490. | |
| |
45. Lane M., Lyons E.A., Bavister B.D. Cryopreservation reduces the ability of hamster 2-cell embryos to regulate intracellular pH. Human Reproduction, 2000; 15(2): 389-394. | |
| |
46. Lang F., Busch G.L., Ritter M. et al. Functional significance of cell volume regulatory mechanisms. Physiol. Rev, 1998; 78: 247-306. | |
| |
47. Letovsky S.I., Cottingham R.W., Porter C.J. et al. GDB: The Human Genome Database. Nucleic Acids Research, 1998; 26(1): 94-99. | |
| |
48. Levine S.A., Montrose M.H., Tse C.-M. et al. Kinetics and Regulation of Three Cloned Mammalian Na+/H+ Exchangers Stably Expressed in a Fibroblast Cell Line. J. Biol. Chem, 1993; 268(34): 25527-25535. | |
| |
49. Li X., Alvarez B., Casey J.R. et al. Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. J. Biol. Chem, 2002; 277: 36085-36091. | |
| |
50. Li X., Liu Y., Alvarez B.V. et al. A novel carbonic anhydrase II binding site regulates NHE1 activity. Biochemistry, 2006; 45(7): 2414-2424. | |
| |
51. Lin Y., Wang J., Jin W. et al. NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP. Cell Biochem. Funct, 2012; 30: 41-46. | |
| |
52. Malo M.E., Fliegel L. Physiological role and regulation of the Na+/H+ exchanger. Can. J. Physiol. Pharmacol, 2006; 84: 1081-1095. | |
| |
53. Masereel B., Pochet L., Laeckmann D. An overview of inhibitors of Na+/H+ exchanger. Eur. J. Med. Chem, 2003; 38: 547-554. | |
| |
54. McLean L.A., Roscoe J., Jorgensen N.K. et al. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. Am. J. Physiol. Cell Physiol, 2000; 278: C676-C688. | |
| |
55. Motais R., Borgese F., Fievet B. et al. Regulation of Na+/H+ exchange and pH in erythrocytes of fish. Comp. Biochem. Physiol, 1992; 102: 597-602. | |
| |
56. Oberstein S.Y., Byun J., Herrera D. et al. Cell proliferation in human epiretinal membranes: characterization of cell types and correlation with disease condition and duration. Mol. Vis, 2011; 17: 1794-1805. | |
| |
57. Olkhova E., Hunte C., Screpanti E. et al. Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications. PNAS, 2006; 103(8): 2629-2634. | |
| |
58. Orlowski J., Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch, 2004; 447(5): 549-65. | |
| |
59. Orlowski J., Grinstein S. Na+/H+ exchangers of mammalian cells. J. Biol. Chem, 1997; 272: 22373-22376. | |
| |
60. Padan E., Kozachkov L., Herz K. et al. NhaA crystal structure: functional-structural insights. J. Exp. Biol, 2009; 212: 1593-1603. | |
| |
61. Padan E., Schuldiner S. Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells. J. Bioenerg. Biomembr, 1993; 25(6): 647-69. | |
| |
62. Padan E., Venturi M., Gerchman Y. et al. Na(+)/H(+) antiporters. Biochim. Biophys. Acta, 2001; 1505(1): 144-57. | |
| |
63. Paradiso A., Cardone R.A., Bellizzi A. et al. The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. Breast Cancer Res, 2004; 6(6): R616-28. | |
| |
64. Pedersen S.F., O'Donnell M.E., Anderson S.E. et al. Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl− cotransport in the heart, brain, and blood. Am. J. Physiol. Regul. Integr. Comp. Physiol, 2006; 291: R1-R25. | |
| |
65. Pepe G.J., Burch M.G., Albrecht E.D. Developmental regulation of the sodium/hydrogen ion exchangers and their regulatory factors in baboon placental syncytiotrophoblast. Endocrinology, 2006; 147(6): 2986-2996. | |
| |
66. Pepe G.J., Burch M.G., Sibley C.P. et al. Expression of the mRNAs and Proteins for the Na(+)/H(+) exchangers and their regulatory factors in baboon and human placental syncytiotrophoblast. Endocrinology, 2001; 42(8): 3685-3692. | |
| |
67. Reshkin S.J., Bellizzi A., Albarani V. et al. Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation. J. Biol. Chem, 2000; 275(8): 5361-9. | |
| |
68. Rezai K., Kulisz A., Wasserman W.J. Protooncogene product, c-mos kinase, is involved in upregulating Na+/H+ antiporter in Xenopus oocytes. Am. J. Physiol. Cell Physiol, 1994; 267(6): C1717-C1722. | |
| |
69. Romero M.F., Fulton C.M., Boron W.F. The SLC4 family of HCO3- transporters. Pflugers Arch, 2004; 447: 495-509. | |
| |
70. Rosskopf D., Dusing R., Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension, 1993; 21: 60-617. | |
| |
71. Rossmann H., Sonnentag T., Heinzmann A. et al. Differential expression and regulation of Na+-H+ exchanger isoforms in rabbit parietal and mucous cells. Am. J. Physiol, 2001; 281: G447-G458. | |
| |
72. Rotin D., Steele-Norwood D., Grinstein S. et al. Requirement of the Na+/H+ exchanger for tumor growth. Cancer Research, 1989; 49(1): 205-211. | |
| |
73. Sacktor B., Kinsella J. Regulation of Na+/H+ exchange activity by adaptive mechanisms. Boca Raton. Fla. CRC Press, 1988: 307-324. | |
| |
74. Sardet C., Franchi A., Pouyssegur J. Molecular cloning, primary struc ture, and expression of the human growth factor-activatable Na+/H+ antiporter. Cell, 1989; 56: 271-280. | |
| |
75. Schelling J.R., Abu Jawdeh B.G. Regulation of cell survival by Na+/H+ exchanger-1. Am. J. Physiol. Renal. Physiol, 2008; 295(3): F625-F632. | |
| |
76. Shen M.R., Wilkins R.J., Chou C.Y. et al. Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells. FEBS, 2002; 512(1-3): 52-8. | |
| |
77. Sherstobitov A.O., Lapin A.V., Glazunov V.V. et al. Accumulation of sodium and potassium ions in oocytes of the river lamprey Lampetra fluviatilis during prespawning period. Zh. Evol. Biokhim. Fiziol, 2011; 47(4): 278-82. | |
| |
78. Silva N.L., Haworth R.S., Singh D. et al. The carboxyl-terminal region of the Na+/H+ exchanger interacts with mammalian heat shock protein. Biochemistry, 1995; 34: 10412-10420. | |
| |
79. Slepkov E.R., Rainey J.K., Sykes B.D. et al. Structural and functional analysis of the Na+/H+ exchanger. Biochem. J, 2007; 401: 623-633. | |
| |
80. Steeves C.L., Lane M., Bavister B.D. et al. Differences in Intracellular pH Regulation by Na+/H+ Antiporter among Two-Cell Mouse Embryos Derived from Females of Different Strains. Biol. Reprod, 2001; 65: 14-22. | |
| |
81. Takaichi K., Wang D., Balkovetz D.F. et al. Cloning, sequencing, and expression of Na+/H+ antiporter cDNAs from human tissues. Am. J. Physiol, 1992; 262: C1069-C1076. | |
| |
82. Titushkin I., Cho M. Altered osteogenic commitment of human mesenchymal stem cells by ERM protein-dependent modulation of cellular biomechanics. J. Biomech, 2011; 44(15): 2692-8. | |
| |
83. Towle D.W., Baksinski A., Richard N.E. et al. Characterization of an endogenous Na+/H+ antiporter in Xenopus laevis oocytes. J. Exp. Biol, 1991; 159: 359-69. | |
| |
84. Tse C.-M., Levine S.A., Yun C.H.C. et al. Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): Resistance to amiloride and inhibition by protein kinase C. Proc. Natl. Acad. Sci, 1993; 90: 9110-9114. | |
| |
85. Venturi M., Rimon A., Gerchman Y. et al. The Monoclonal Antibody 1F6 Identifies a pH-dependent Conformational Change in the Hydrophilic NH2 Terminus of NhaA Na+/H+ Antiporter of Escherichia coli. J. Biol. Chem, 2000; 275: 4734-4742. | |
| |
86. Vila-Petroff M., Mundiсa-Weilenmann C., Lezcano N., et al. Ca2+/calmodulin dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na+/H+ exchanger activation. J. Mol. Cell Cardiol, 2010; 49(1): 106-112. | |
| |
87. Wakabayashi S., Bertrand B., Shigekawa M. et al. Growth factor activation and "H(+)-sensing" of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation. J. Biol. Chem, 1994; 269(8): 5583-5588. | |
| |
88. Wakabayashi S., Bertrand B., Ikeda T. et al. Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H+-sensitive and Ca2+ regulation-defective. J. Biol. Chem, 1994; 269: 13710-13715. | |
| |
89. Wakabayashi S., Fafournoux P., Sardet C. et al. The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls 'H+ sensing'. Proc. Natn. Acad. Sci. U.S.A, 1992; 89: 2424-2428. | |
| |
90. Wakabayashi S., Hisamitsu T., Pang T. et al. Kinetic Dissection of Two Distinct Proton Binding Sites in Na+/H+ Exchangers by Measurement of Reverse Mode Reaction. J. Biol. Chem, 2003; 278(44): 43580-43585. | |
| |
91. Wakabayashi S., Ikeda T., Iwamoto T. et al. Calmodulin-binding autoinhibitory domain controls «pH-sensing» in the Na+/H+ exchanger NHE1 through sequence-specific interaction. Biochemistry, 1997; 36: 12854-12861. | |
| |
92. Wakabayashi S., Pang T., Su X. et al. A novel topology model of the human Na+/H+ exchanger isoform 1. J. Biol. Chem, 2000; 275: 7942-7949. | |
| |
93. Wakabayashi S., Shigekawa M., Pouyssegur J. Molecular physiology of vertebrae Na+/Н+ exchangers. Physiol. Rev, 1997; 77(5): 1-74. | |
| |
94. Wang H., Singh D., Fliegel L. The Na+/H+ Antiporter Potentiates Growth and Retinoic Acid-induced Differentiation of P19 Embryonal Carcinoma Cells. J. Biol. Chem, 1997; 272(42): 26545-26549. | |
| |
95. Weaver Y.R., Kiessling K., Cossins A.R. Responses of the Na+/H+ exchanger of european flounder red blood cells to hypertonic, b-adrenergic and acidotic stimuli. J. Exp. Biol, 1999; 202: 21-32. | |
| |
96. Xue J., Zhou D., Yao H. et al. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. AJP - Regu. Physiol, 2007; 292(6): R2406-R2416. | |
| |
97. Yonemura S., Tsukita S., Tsukita S. Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins. J. Cell Biol, 1999; 145: 1497-1509. | |
| |
98. Yun C. H. C., Tse C.-M., Donowitz M. Chimeric Na+/H+ exchangers: An epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases. Proc. Natl. Acad. Sci, 1995; 92: 10723-10727. | |
| |
99. Zadunaisky J.A., Kinne-Saffraaf E., Kinne R. Na/H Exchange Mechanism in Apical Membrane Vesicles of the Retinal Pigment Epithelium. Investigative Ophthalmology & Visual Science, 1989; 30(11): 2332-2340. | |
| |
100. Zhao Y., Chauvet P.J., Alper S.L. et al. Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo. J. Biol. Chem, 1995; 270: 24428-24434. | |
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