EFFECT OF NIPASOL ON COMPOSITION OF LUMINAL MICROFLORA IN LARGE INTESTINE OF WHITE RATS
DOI: http://dx.doi.org/10.30970/sbi.0703.311
Abstract
The effect of the antimicrobial preservative nipasol on qualitative and quantitative composition of large intestine microflora in rats was studied. It was established that representatives of genera Bacteroides, Bifidobacterium, Lactobacillus, Escherichia, Enterococcus, Staphylococcus, Eubacterium, Fusobacterium, Prevotella are among residential bacteria which inhabit lumen of intestine of rats of the control group. Bacteria of genera Peptostreptococcus, Peptococcus, Proteus, Clostridium, Streptococcus and fungi Candida sp. may be ranged to facultative luminal microflora of animals. We have established that administration of nipasol in 10 mg/kg dose led to a decrease in number of representatives of genera Bifidobacterium, Enterococcus, Escherichia, Candida (on 4th day of study), Eubacterium, Peptostreptococcus (on 7th day), Peptococcus, Lactobacillus (on 11th day). Under these conditions, an increase in number of bacteria of genera Proteus and Staphylococcus, Clostridium and Fusobacterium was observed on 4th, 7th and 14th daysy, respectively. Besides, lactose negative bacteria belonging to genus Escherichia and Klebsiella spp. were revealed in large intestine of rats treated with nipasol. Microorganisms belonging to genera Clostridium, Prevotella, Proteus, Klebsiella and lactose negative of Escherichia sp. were constant representatives of microflora of given biotope under the effect of nipasol compared with such microorganisms in animals of control group.
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