AGE-DEPENDENT CHANGES IN GASTROINTESTINAL MOTILITY

O. Iefimenko; I. Savchenko; T. Beregova

doi:10.30970/sbi.0702.273

AGE-DEPENDENT CHANGES IN GASTROINTESTINAL MOTILITY

O. Iefimenko, I. Savchenko, T. Beregova

DOI: http://dx.doi.org/10.30970/sbi.0702.273

Abstract

The mechanisms of the motor function are studied for more than 100 years, however, they have not been established completely. Understanding those mechanisms is of great importance since the disturbances of gastrointestinal motility underlay in pathogeneses of many diseases, such as colitis, constipations, irritable bowel syndrome and others. This review is devoted to analysis of literature data of the age-related changes in the motility function of digestive tract. We have searched articles on a particular issue and have analyzed them in accordance with the parts of the digestive tract. Main attention has been paid to age-dependent functional and regulatory changes in the digestive tract. The mechanisms underlying in pathogenesis of age-related diseases of motor function of the digestive tract have not been deeply studied. Without the establishment of these mechanisms, it is impossible to create new drugs for prophylaxis and treatment of age-related disturbances in motor function of the gastrointestinal (GI) motility.

Keywords

gastrointestinal motility, age

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References

1. Abalo R., Vera G., Rivera A.J. et al. Age-related changes in the gastrointestinal tract: a functional and immunohistochemical study in guinea-pig ileum. Life Sci, 2007; 80(26): 2436-45. https://doi.org/10.1016/j.lfs.2007.04.004 PMid:17509618

2. Baker D.M., Santer R.M. A quantitative study of the effects of age on the noradrenergic innervation of Auerbach's plexus in the rat . Mech. Ageing. Dev, 1988a; 42: 147-158. https://doi.org/10.1016/0047-6374(88)90070-X

3. Bannister J.J. Abouzekry L., Read N.W. Effect of aging on anorectal function. Gut,1987; 28: 353-357. https://doi.org/10.1136/gut.28.3.353 PMid:3570039 PMCid:PMC1432698

4. Barrett J.A., Brocklehurst J.C., Kiff E.S. Anal function in geriatric patients with faecal incontinence. Gut, 1989; 30(9): 1244-1251. https://doi.org/10.1136/gut.30.9.1244 PMid:2806992 PMCid:PMC1434236

5. Bergman E., Ulfhake B. Loss of primary sensory neurons in the very old rat: neuron number estimates using the disector method and confocal optical sectionin. J. Comp. Neurol, 1998; 396: 211-222. https://doi.org/10.1002/(SICI)1096-9861(19980629)396:2<211::AID-CNE6>3.3.CO;2-T

6. Bitar K., Greenwood-Van Meerveld B. Aging and gastrointestinal neuromuscular function: insights from within and outside the gut. Neurogastroenterol. Motil, 2011; 23(6): 490-501. https://doi.org/10.1111/j.1365-2982.2011.01678.x PMid:21320236 PMCid:PMC3094479

7. Brogna A. Ferrara R., Bucceri A.M. Influence of aging on gastrointestinal transit time. An ultrasonographic and radiologic study. Invest. Radiol, 1999; 34: 357-359. https://doi.org/10.1097/00004424-199905000-00005 PMid:10226848

8. Bhutto A., Morley J.E. The clinical significance of gastrointestinal changes with aging. Curr. Opin. Clin. Nutr. Metab. Care, 2008; 11(5): 651-660. https://doi.org/10.1097/MCO.0b013e32830b5d37 PMid:18685464

9. Castell D.O. Esophageal disorders in the elderly. Gastroenterol. Clin. North. Am, 1990; 19(2): 235-238.

10. Chiocchetti R., Grandis A., Bombardi C. Extrinsic and intrinsic sources of calcitonin gene-related peptide immunoreactivity in the lamb ileum: a morphometric and neurochemical investigation. Cell Tissue Res, 2006; 323: 183-196. https://doi.org/10.1007/s00441-005-0075-2 PMid:16228232

11. Cowen T., Johnson R.J., Soubeyre V. Restricted diet rescues rat enteric motor neurones from age related cell death. Gut, 2000; 47(5): 653-660. https://doi.org/10.1136/gut.47.5.653 PMid:11034581 PMCid:PMC1728112

12. De Souza R.R., Moratelli H.B., Borges N. Age-induced nerve cell loss in the myenteric plexus of the small intestine in man. Gerontology, 1993; 39(4): 183-188. https://doi.org/10.1159/000213532 PMid:8244045

13. Di Lorenzo C., Flores A.F., Hyman P.E. Age-related changes in colon motility. J. Pediatr, 1995; 127(4): 593-596. https://doi.org/10.1016/S0022-3476(95)70120-6

14. El-Salhy M., Sandström O., Holmlund F. Age-induced changes in the enteric nervous system in the mouse. Mech. Ageing. Dev, 1999; 107(1): 93-103. https://doi.org/10.1016/S0047-6374(98)00142-0

15. Ergun G.A., Miskovitz P.F. Aging and the esophagus: common pathologic conditions and their effect upon swallowing in the geriatric population. Dysphagia, 1992; 7: 58-63. https://doi.org/10.1007/BF02493434

16. Evans M.A., Triggs E.J., Cheung M.J. Gastric emptying rate in the elderly: implications for drug therapy. Am. Geriatr. Soc, 1981; 29(5): 201-205. https://doi.org/10.1111/j.1532-5415.1981.tb01766.x PMid:6262396

17. Farrugia G. Interstitial cells of Cajal in health and disease. Neurogastroenterol. Motil, 2008; 20: 54-63. https://doi.org/10.1111/j.1365-2982.2008.01109.x PMid:18402642

18. Ferriolli E., Dantas R.O., Oliveira R.B., Braga F.J. The influence of ageing on oesophageal motility after ingestion of liquids with different viscosities. Eur. J. Gastroenterol. Hepatol, 1996; 8(8): 793-798.

19. Ferriolli E., Oliveira R.B., Matsuda N.M. Aging, esophageal motility, and gastroesophageal reflux. Am. Geriatr. Soc, 1998; 46(12): 1534-1537. https://doi.org/10.1111/j.1532-5415.1998.tb01538.x PMid:9848814

20. Fich A., Camilleri M., Phillips S.F. Effect of age on human gastric and small bowel motility. J. Clin. Gastroenterol, 1989; 11(4): 416-420. https://doi.org/10.1097/00004836-198908000-00014 PMid:2760431

21. Firth M., Prather C.M. Gastrointestinal motility problems in the elderly patient. Gastroenterology, 2002; 122: 1688-1700. https://doi.org/10.1053/gast.2002.33566 PMid:12016432

22. Fulp S.R., Dalton C.B., Castell J.A. Aging-related alterations in human upper esophageal sphincter function. Am. J. Gastroenterol, 1990; 85: 1569-1572.

23. Furuta K., Kushiyama Y., Kawashima K., Shibagaki K. Comparisons of symptoms reported by elderly and non-elderly patients with GERD. J. Gastroenterol, 2012; 47(2):144-149. https://doi.org/10.1007/s00535-011-0476-9 PMid:21983929

24. Gabella G. Fall in the number of myenteric neurons in aging guinea pigs. Gastroenterology, 1989;. 96(6): 1487-1493. https://doi.org/10.1016/0016-5085(89)90516-7

25. Gai W.P., Blumbergs P.C., Geffen L.B. Age-related loss of dorsal vagal neurons in Parkinson's disease. Neurology, 1992; 42(11): 2106-2111. https://doi.org/10.1212/WNL.42.11.2106 PMid:1436519

26. Gomez-Pinilla Pedro J. Changes in Interstitial Cells of Cajal with Age in the Human Stomach and Colon. Neurogastroenterol. Motil, 2011; 23: 36-44. https://doi.org/10.1111/j.1365-2982.2010.01590.x PMid:20723073 PMCid:PMC2999641

27. Grande L., Lacima G., Ros E. Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects. Am. J. Gastroenterol, 1999; 94: 1795-1801. https://doi.org/10.1016/S0002-9270(99)00264-6

28. Green T., Dockray G.J. Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat. Neurosci. Lett, 1987; 76: 151-156. https://doi.org/10.1016/0304-3940(87)90707-5

29. Herwaarden M.A., Katz P.O., Gideon R.M., Barrett J. Are manometric parameters of the upper esophageal sphincter and pharynx affected by age and gender? Dysphagia, 2003; 18(3): 211-217. https://doi.org/10.1007/s00455-002-0099-7 PMid:14506987

30. Hoyle C.H., Saffrey M.J. Effects of aging on cholinergic neuromuscular transmission in isolated small intestine of ad libitum fed and calorically-restricted rats. Neurogastroenterol. Motil, 2012; 24(6): 586-92. https://doi.org/10.1111/j.1365-2982.2012.01913.x PMid:22435850

31. Hopkins M.J., Sharp R., Macfarlane G.T. Variation in human intestinal microbiota with age. Dig. Liver Dis, 2002; 34: S12-18. https://doi.org/10.1016/S1590-8658(02)80157-8

32. Husebye E., Engedal K. The patterns of motility are maintained in the human small intestine throughout the process of aging. Scand. J. Gastroenterol,1992; 27(5): 397-404. https://doi.org/10.3109/00365529209000095 PMid:1529275

33. Ibitayo A.I., Tsunoda Y., Nozu F. Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle. Am. J. Physiol, 1998; 275: G705-G711. https://doi.org/10.1152/ajpgi.1998.275.4.G705 PMid:9756500

34. Ibitayo A.I., Sladick J., Tuteja S. HSP27 in signal transduction and association with contractile proteins in smooth muscle cells. Am. J. Physiol, 1999; 277: G445-G454. https://doi.org/10.1152/ajpgi.1999.277.2.G445 PMid:10444459

35. Kang H.W., Jung H.K., Kwon K.J. Prevalence and predictive factors of fecal incontinence. J. Neurogastroenterol. Motil, 2012; 18(1): 86-93. https://doi.org/10.5056/jnm.2012.18.1.86 PMid:22323992 PMCid:PMC3271259

36. Laurberg S., Swash M. Effects of aging on the anorectal sphincters and their innervations. Dis. Colon. Rectum, 1989; 32(9): 737-742. https://doi.org/10.1007/BF02562120 PMid:2758941

37. Lee Y., Shiotani Y., Hayashi N. Distribution and origin of calcitonin gene-related peptide in the rat stomach and duodenum: an immunocytochemical analysis. J. Neural. Transm, 1987; 68: 1-14. https://doi.org/10.1007/BF01244635 PMid:3543218

38. Lee J., Anggiansah A., Anggiansah R., Young A. Effects of age on the gastroesophageal junction, esophageal motility, and reflux disease. Clin. Gastroenterol. Hepatol, 2007; 5(12): 1392-1398. https://doi.org/10.1016/j.cgh.2007.08.011 PMid:17936081

39. Madsen J.L. Evffects of gender, age, and body mass index on gastrointestinal transit times. Dig. Dis. Sci, 1992; 37(10):1548-1553. https://doi.org/10.1007/BF01296501 PMid:1396002

40. Madsen J.L., Graff J. Effects of ageing on gastrointestinal motor function. Age Ageing, 2004; 33(2): 154-159. https://doi.org/10.1093/ageing/afh040 PMid:14960431

41. Marín J. Age-related changes in vascular responses: a review. Mech. Ageing. Dev, 1995; 79: 71-114. https://doi.org/10.1016/0047-6374(94)01551-V

42. Meciano Filho J., Carvalho V.C., de Souza R.R. Nerve cell loss in the myenteric plexus of the human esophagus in relation to age: a preliminary investigation. Gerontology, 1995; 41(1): 18-21. https://doi.org/10.1159/000213658 PMid:7737530

43. Meir R., Beglinger C., Dederding J.P. Age- and sex-specific standard values of colonic transit time in healthy subjects. Schweiz. Med. Wochenschr, 1992; 122(24): 940-943.

44. Morley J.E. The aging gut: physiology. Clin. Geriatr. Med, 2007; 23(4): 757-767. https://doi.org/10.1016/j.cger.2007.06.002 PMid:17923336

45. O'Donnovan D., Hausken T., Lei Y. Effect of aging on transpyloric flow, gastric emptying, and intragastric distribution in health humans: impact on glycemia. Dig. Dis. Sci, 2005; 50: 671-676. https://doi.org/10.1007/s10620-005-2555-3 PMid:15844700

46. O'Mahony D., O'Leary P., Quigley E.M. Aging and intestinal motility: a review of factors that affect intestinal motility in the aged. Drugs Aging, 2002; 19: 515-527. https://doi.org/10.2165/00002512-200219070-00005 PMid:12182688

47. Orr W.C., Chen C.L. Aging and neural control of the GI tract: IV. Clinical and physiological aspects of gastrointestinal motility and aging. Am. J. Physiol. Gastrointest. Liver. Physiol, 2002; 283: G1226-G1231. https://doi.org/10.1152/ajpgi.00276.2002 PMid:12433662

48. Phillips R.J., Powley T.L. As the gut ages: timetables for aging of innervation vary by organ in the Fischer 344 rat. J. Comp. Neurol, 2001; 434(3): 358-377. https://doi.org/10.1002/cne.1182 PMid:11331534

49. Phillips R.J., Rhodes B.S., Powley T.L. Effects of age on sympathetic innervation of the myenteric plexus and gastrointestinal smooth muscle of Fischer 344 rats. Anat. Embryol. (Berl), 2006; 211(6): 673-683. https://doi.org/10.1007/s00429-006-0123-z PMid:17024301

50. Phillips R.J., Rhodes B.S., Powley T.L. Age-related neuronal loss in the submucosal plexus of the colon of the Fischer 344 rats. Neurobiol Aging, 2006a; 43: 17-29.

51. Phillips R.J., Powley T. Innervation of the gastrointestinal tract: patterns of aging. Auton. Neurosc, 2007; 136: 1-19. https://doi.org/10.1016/j.autneu.2007.04.005 PMid:17537681 PMCid:PMC2045700

52. Powley T.L., Phillips R.J. Advances in neural tracing of vagal afferent nerves and terminals. Methods and New Frontiers in Neuroscience, 2005; 28: 123-145. https://doi.org/10.1201/9780203492314.pt3

53. Rayner C.K., MacIntosh C.G., Chapman I.M. Effects of age on proximal gastric motor and sensory function. Scand. J. Gastroenterol, 2000; 35(10): 1041-1047. https://doi.org/10.1080/003655200451153

54. Rayner C.K., Horowitz M. Physiology of the ageing gut. Curr. Opin. Clin. Nutr. Metab. Care, 2013; 16(1): 33-38. https://doi.org/10.1097/MCO.0b013e32835acaf4 PMid:23095947

55. Ren J., Shaker R., Kusano M., Podvrsan B. Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am. J. Physiol, 1995; 268: G772-779. https://doi.org/10.1152/ajpgi.1995.268.5.G772 PMid:7762661

56. Roberts D., Gelperin D., Wiley J.W. Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon. Am. J. Physiol, 1994; 267: G515-22. https://doi.org/10.1152/ajpgi.1994.267.4.G515 PMid:7943316

57. Ryhammer A.M. Laurberg S., Srensen F.H. Effects of age on anal function in normal women. Int. J. Colorectal. Dis, 1997; 12: 225-229. https://doi.org/10.1007/s003840050094 PMid:9272452

58. Saad R.J., Semler J.R., Wilding G.E. The effects of age on regional and whole gut transit times in healthy adults. Gastroenterol, 2010; 138: S-127. https://doi.org/10.1016/S0016-5085(10)60581-1

59. Sadik R., Abrahamsson H., Stotzer P.O. Gender differences in gut transit shown with a newly developed radiological procedure. Scand. J. Gastroenterol, 2003; 38(1): 36-42. https://doi.org/10.1080/00365520310000410 PMid:12608462

60. Salles N. Basic mechanisms of the aging gastrointestinal tract. Dig. Dis, 2007; 25(2): 112-117. https://doi.org/10.1159/000099474 PMid:17468545

61. Santer R.M., Baker D.M. Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats. J. Auton. Nerv. Syst, 1988; 25(1): 59-67. https://doi.org/10.1016/0165-1838(88)90008-2

62. Santer R.M., Dering M.A., Ranson R.N. Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs. Auton. Neurosci, 2002; 96: 73-81. https://doi.org/10.1016/S1566-0702(01)00366-6

63. Shaker R., Ren J., Podvrsan B., Dodds W.J. Effect of aging and bolus variables on pharyngeal and upper esophageal sphincter motor function. Am. J. Physiol, 1993; 264: G427-32. https://doi.org/10.1152/ajpgi.1993.264.3.G427 PMid:8460698

64. Shimamoto C., Hirata I., Hiraike Y., Takeuchi N. Evaluation of gastric motor activity in the elderly by electrogastrography and the (13)C-acetate breath test. Gerontology, 2002; 48(6): 381-386. https://doi.org/10.1159/000065500 PMid:12393954

65. Smits G.J. Influence of age on cholinergic and inhibitory nonadrenergic noncholinergic responses in the rat ileum. Eur. J. Pharmacol, 1996; 303: 79-86. https://doi.org/10.1016/0014-2999(96)00089-1

66. Tack J., Vantrappen G. The aging oesophagus. Gut, 1997; 41(4): 422-424. https://doi.org/10.1136/gut.41.4.422 PMid:9391234 PMCid:PMC1891523

67. Thrasvoulou C., Soubeyre V., Ridha H. Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons. Aging. Cell, 2006; 5(3): 247-57. https://doi.org/10.1111/j.1474-9726.2006.00214.x PMid:16842497

68. Vanner S. Corelease of neuropeptides from capsaicin-sensitive afferents dilates submucosal arterioles in guinea pig ileum. Am. J. Physiol, 1994; 267: G650-655. https://doi.org/10.1152/ajpgi.1994.267.4.G650 PMid:7524349

69. Xiong Z., Sperelakis N., Noffsinger A., Fenoglio-Preiser C. Potassium currents in rat colonic smooth muscle cells and changes during development and aging. Pflugers. Arch, 1995; 430: 563-72. https://doi.org/10.1007/BF00373893 PMid:7491283

70. Wadel P. R., Cowen T. Neurodegeneration: a key factor in the ageing gut. Neurogastroenterology. Motil, 2004; 16: 19-23. https://doi.org/10.1111/j.1743-3150.2004.00469.x PMid:15065999

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Biologichni Studii / Studia Biologica

AGE-DEPENDENT CHANGES IN GASTROINTESTINAL MOTILITY

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