SUGAR-LOWERING EFFECTS OF WATER EXTRACTS OF YAKON (SMALLANTHUS SONCHIFOLIUS POEPP. & ENDL.)

A. V. Horbulinska, M. R. Khokhla, L. T. Mishchenko, G. Ya. Hachkova, N. O. Sybirna


DOI: http://dx.doi.org/10.30970/sbi.0802.350

Abstract


The article contains data on the influence of yakon (Smallanthus Sonchifolius Poepp. & Endl.) root as well as aerial parts water extracts on glucose tolerance. The use of aqueous extracts of yakon aerial parts contributed to a significant increase of glucose (glu) tolerance. This led to significant reduction of integrated glycemic index – the area under the curve of glucose (AUCglu). In particular it was established that the use of yakon leaf extract causes the decline of AUCglu by 30.2 % in comparison with the control, while the use of petioles and stems extracts provided reduction of AUCglu to 20.7 and 17.2 %, respectively. Comparative analysis of the hypoglycemic action of yakon root water extracts in healthy animals suggests that yakon tubers extract has more pronounced hypoglycemic effect, whase use resulted in reduction of AUCglu to 39.4 %, while the tuber peel extract caused a reduction of this index to 29.9 %. Thus, conducted research of antidiabetic properties of yakon extracts allow to recommend aqueous extracts of its leaves and root tubers as effective hypoglycemic agents.


Keywords


yakon (Smallanthus sonchifolius Poepp. & Endl.), diabetes, hypoglycemic effect

References


1. Baroni S., Suzuki-Kemmelmeier S.M., Caparroz-Assef R.K.N. Effect of crude extracts of leaves of Smallanthus sonchifolius (yacon) on glycemia in diabetic rats. Journal of Pharmaceutical Sciences, 2008; 44(3): 522-530.
https://doi.org/10.1590/S1516-93322008000300024

2. Castro А., Caballero M., Herbas A., Carballo S. Antioxidants in yacon products and effect of long term storage. Ciênc. Tecnol. Aliment, 2012; 32(3): 432-435.
https://doi.org/10.1590/S0101-20612012005000064

3. Dashchenko A.V., Dunich A.A., Mishchenko L.T. Morphological characteristics of yakon, introduced in Ukraine. Proceedings Conf. Young Scientists. Current issues of technical herbs, 2011: 25-28. (In Ukrainian)

4. Dunych A.A., Dashchenko A.V., Sereda A.V. et al. Phenolic compounds yakon (Polymnia sonchifolia Poepp. & Endl.) Ukrainian introductions. VIII International Symposium on phenolic compounds: fundamental and applied aspects, 2012: 66-71. (In Russian)

5. Dou D.Q., Kang T.G., Qiu Y.K., Tian F. Studies on the Anti-diabetic Constituents of the Leaves of Smallantus sonchifolius (Yacon). Planta Med, 2008; 74: 71.
https://doi.org/10.1055/s-2008-1075267

6. Ferents I.V., Brodyak I.V., Lyuta M.Y. et al. Effect of agmatine on the blood system parameters of rats under the condition of experimental diabetes mellitus. Biological Studies/Studia Biologica, 2012; 6(3): 65-72. (In Ukrainian)
https://doi.org/10.30970/sbi.0603.241

7. Genta S.B., Cabrera W.M., Mercado M.I. et al. Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: Constituents of the most active fractions. Chem. Biol. Interact, 2010; 185(2):143-152.
https://doi.org/10.1016/j.cbi.2010.03.004
PMid:20211156

8. Goto K., Fukai K., Hikida J. et al. Isolation and structural analysis of oligosaccharides from yacon (Polymnia sonchifolia). Biosci. Biotechnol. Biochem, 1995; 59: 2346-2347.
https://doi.org/10.1271/bbb.59.2346

9. Grau A., Rea J. Yacon Smallanthus sonchifolius (Poepp. et Endl.) H. Robinson. Andean roots and tubers: ahipa, arracacha, maca and yacon. PK, Gatersleben/IPGRI, 1997: 199-242.

10. Gupta R.K., Kesari A.N., Murthy P.S. et al. Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J. Ethnopharmacol, 2005; 99: 75-81.
https://doi.org/10.1016/j.jep.2005.01.048
PMid:15848023

11. Hong S.S., Lee S.A., Han X.H., Lee M.H. Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS - Induced Nitric Oxide Production. Chem. Pharm. Bull, 2008; 56(2): 199-202.
https://doi.org/10.1248/cpb.56.199
PMid:18239309

12. Honoré S.M. Protective effect of yacon leaves decoction against early nephropathy in experimental diabetic rats. Food Chem. Toxicol, 2012; 50(5): 1704-1715.
https://doi.org/10.1016/j.fct.2012.02.073
PMid:22406203

13. Itaya N.M., De Carvalho M.A.M., Figueiredo-Ribeiro R.D.L. Fructosyl transferase and hydrolase activities in rhizophores and tuberous roots upon growth of Polymnia sonchifolia (Asteraceae). Physiol. Plant, 2002; 116: 451-459.
https://doi.org/10.1034/j.1399-3054.2002.1160403.x

14. Kononkov P.F., Pyvovarov V.F., Hyns M.S., Hyns V.K. Introduction and selection of vegetables to create a new generation of functional actions. Peoples Friendship University of Russia, 2008. 170 p. (In Russian)

15. Lachman J., Fernаndez E.C., Orsаk M. Smallanthus sonchifolia (Poepp. et Endl.) H. Robinson chemical composition and use - a review. Plant Soil Environ, 2003; 6(49): 283-290.
https://doi.org/10.17221/4126-PSE

16. Lachman J., Fernandez E., Viehmannova I. et al. Total phenolic content of yacon (Smallanthus sonchifolius) rhizomes, leaves, and roots affected by genotype. New Zealand Journal of Crop and Horticultural Science, 2007; 35(1):117-123.
https://doi.org/10.1080/01140670709510175

17. Marles R.F., Fansworth N.R. Antidiabetic plants and their active constituents. Phytomedicine, 1995; 2: 137-189.
https://doi.org/10.1016/S0944-7113(11)80059-0

18. Mishchenko L.T. New vegetable and herbs in Ukraine. Scientific Herald NUBIP Ukraine "Agriculture". Kiev, 2012: 250-255. (In Ukrainian)

19. Miura T. Antidiabetic activity of fuscoporia oblique and Smallanthus sonchifolius in genetically type 2 diabetic mice. Journal of Traditional Medicines, 2007; 24(2): 47-50.

20. Ohyama T., Ito O., Yasuyoshi S. et al. Composition of storage carbohydrate in tuber roots of yacon (Polymnia sonchifolia). Soil Sci. Plant. Nutr, 1990; 36: 167-171.
https://doi.org/10.1080/00380768.1990.10415724

21. Paolisso G., Rizzo M., Barbieri M. Cardiovascular risk in type 2 diabetics and pharmacological regulation of mealtime glucose excursions. Diabetes Metab, 2003; 29: 335-340.
https://doi.org/10.1016/S1262-3636(07)70044-7

22. Park J.S., Yang J.S., Hwang B.Y. et al. Hypoglycemic effect of Yacon tuber extract and Its constituent, chlorogenic acid, in streptozotocin-induced diabetic rats. Biomolecules & Therapeutics, 2009; 17(3): 256-262.
https://doi.org/10.4062/biomolther.2009.17.3.256

23. Rolim P.M., Salgado S.M., Padilha V.M. et al. Glycemic profile and prebiotic potential "in vitro" of bread with Yacon (Smallanthus sonchifolius) flour. Tecnol. Aliment, 2011; 31(2): 474-467.
https://doi.org/10.1590/S0101-20612011000200029

24. Satoh H., Nguyen M.T.A., Kudoh A., Watanabe T. Yacon diet (Smallanthus sonchifolius, Asteraceae) improves hepatic insulin resistance via reducing Trb3 expression in Zucker fa/fa rats. Nutrition & Diabetes, 2013; 3: 1-6.
https://doi.org/10.1038/nutd.2013.11
PMid:23712282 PMCid:PMC3671746

25. Valentová K., Frček J., Ulrichová J. Yacon (Smallanthus sonchifolius) and Maca (Lepidium meyenii), traditional. Andean crops as new functional foods on the European market. Chem. Listy, 2001; 95: 594-601.

26. Valentova K., Moncion A., Waziers I., Ulrichova J. The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism. Cell Biol. Toxicol, 2005; 20: 109-120.
https://doi.org/10.1023/B:CBTO.0000027931.88957.80
PMid:15242186

27. Volpato G.T., Vieira F.L., Almeida F.C.G. et al. Study of the hypoglycemic effects of Polymnia sonchifolia leaf extracts in rats. Pharmacognosy, Pharmacology, Phytomedicine, Toxicology, 1999, 319.

28. Yan X., Suzuki M., Ohnishi-Kameyama M. et al. Extraction and Identification of antioxidants in the roots of yacon (Smallanthus sonchifolius). Journal of Agricultural and Food Chemistry,1999; 47(11): 4711-4713.
https://doi.org/10.1021/jf981305o
PMid:10552877

29. Yeh S.T. Using trapezoidal rule for the area under a curve calculation. Proceedings of the Twen¬ty-Seventh Annual SAS. User Group International (SUGI) Conference, 2002; 27: 229-37.


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