PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF AN INTRODUCED AMPELOPSIS BREVIPEDUNCULATA (MAXIM.) TRAUTV.
DOI: http://dx.doi.org/10.30970/sbi.2001.867
Abstract
Background. Ampelopsis brevipedunculata (Maxim.) Trautv (AB) is recognized for its potential in the treatment of hepatotoxic conditions, atopic dermatitis, and skin inflammation, which may be due to the synergism of certain bioactive compounds. The aim was to evaluate the ability of AB leaf extracts as antimicrobial agents against Escherichia coli, Bacillus subtilis, Candida parapsilosis, and to improve the understanding of the influence of polyphenols, flavonoids, hydroxycinnamic acids, carotenoids, and chlorophylls in their composition on antimicrobial activity.
Methods. The AB leaf aqueous ethanol (AE) extracts were obtained using the reflux condition and maceration methods. Spectrophotometric analysis was used for the calculation of phenolic compounds, flavonoids, and hydroxycinnamic acids total content, chlorophyll, and carotenoids content in the extracts. The antimicrobial activity of the extracts of AB (ABEs) were assessed by the agar diffusion method.
Results. Distilled water, 20 %, 60 % AE, and 96 % E provided high extraction of polyphenols by both methods, and 96 % Е for carotenoids and chlorophylls. E. coli and C. parapsilosis were not sensitive to the aqueous extract and the extract prepared with 20 % AE by maceration. At the same time, ABEs prepared with 60 % AE and 96 % Е had a certain inhibitory effect on E. coli and C. parapsilosis. B. subtilis was inhibited by the aqueous extract. Correlation analysis confirmed the relationships between the studied biological active substances and the diameter of the growth inhibition zones of the tested cultures. Two-factor analysis of variance confirmed the reliability of the proportions of the influence on the zones of inhibition of the studied cultures in the control and ABEs when using the maceration method, as well as ABEs obtained when using 20 % АЕ.
Conclusion. ABEs are a rich and diverse source of biochemicals that have inhibitory effects against E. coli, B. subtilis, and C. parapsilosis. ABEs can be used as a rich source of phenols, flavonoids, hydroxycinnamic acids, chlorophylls and carotenoids for further research, and use as antimicrobial agents.
Keywords
Ampelopsis brevipedunculata, green extracts, antimicrobial activity, biologically active substances
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