АКТИВНІСТЬ ОРНІТИНДЕКАРБОКСИЛАЗИ ТА ТІОЛ-ДИСУЛЬФІДНИЙ СТАТУС КЛІТИН СЛИЗОВОЇ ОБОЛОНКИ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ ПІДВИЩЕНОМУ СПОЖИВАННІ NaCl

Анотація

The aim was to determine ornithine decarboxylase (ODC) activity, content of reduced (GSH) and oxidized (GSSG) glutathione in rat gastric mucosa cells under NaCl higher intake condition. White male rats underwent 10-week replacement of standard vivarium diet on diet containing 5 % NaCl. After this period expiry the animals were fed with standard vivarium diet till the end of the 12th week. Gastric mucosa cells were extracted at the end of the 4th, 6th, 8th, 10th and 12th week. The decrease of GSH/GSSG ratio pointed to the oxidative state of gastric cells, and increased ODC activity at the end of a 2-week abolation may have indicated reparative regeneration.