INFLUENCE OF WORTMANNIN ON AGGREGATION ABILITY ON NEUTROPHILIC GRANULOCYTES UNDER TYPE 1 DIABETES MELLITUS

M. Zdioruk, M. Barska, I. Brodyak, O. Vovk, A. Urbanovich, N. Sybirna


DOI: http://dx.doi.org/10.30970/sbi.0302.046

Abstract


The determination wortmanin influence on aggregation ability of neutro­phylic granulocytes induced by specific lectins such as WGA, SNA and MAA was conducted. Distinct functional changes of the leucocytes under type 1 diabetes mellitus contingently by quantitative increasing of plasmatic membrane sialic containing glycoprotein receptors which contain in their structure NeuNAc(α2→6)DGal/DgalNAc carbohydrate, but not NeuNAc(α2→3)DGal/DgalNAc carbohydrate were revealed. Enhanced ability of neutrophylic granulocytes aggregation under influence of specific lectins at type 1 diabetes mellitus and weak answer of wortmanin inhibition may used as test system for determination of dearrangements in functional changes of the leukocytes under type 1 diabetes mellitus.


Keywords


neutrohylic granulocytes, sialic containing glycoprotein, lectin induced aggregation, type 1 diabetes mellitus

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