LEVEL OF PHYSIOLOGICAL FORM OF PRION IN BRAIN AND SPLEEN AND ANTI-prpc – ANTIBODIES IN BLOOD SECUM OF MICE IS DEPENDENT OF THEIR RATION

M. R. Kozak, Yu. Ya. Kit, V. V. Vlizlo, V. V. Stadnyk, R. S. Stoika


DOI: http://dx.doi.org/10.30970/sbi.0301.026

Abstract


It was found that long term feeding of mice with ration supplemented with cattle brain and meat-bone meal (1:1) resulted in producing  cellular form of prion in organs of prion-replicated system (brain and spleen) and anti-PrPc antibodies in blood serum. The effect of ration on potential development of transmissible spongiform encepha­lopathies is discussed.


Keywords


prion, mice, ration, brain, spleen, antibodies

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