MECHANISMS OF CELL DEATH IN NEURODEGENERATIVE PROCESSES
DOI: http://dx.doi.org/10.30970/sbi.0403.117
Abstract
Processes of apoptotic cell death as the main mechanism of neurodegeneration in different types of pathologies are described. Evidence is presented on cell cycle activation in differentiated neurons and on relation between proliferation factors and regulation of neuron death. Hypothesis is referred on possible therapeutic strategies of the mechanisms of pathogenesis of degenerative diseases of nervous system.
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1. Beal M., Flint N. Parkinson's disease. Experimental models of Parkinson's disease. Nature Rev. Neuroscience, 2001; 2: 325-334. | |
| |
2. Bossy-Wetzel E., Barsoum M., Godzik A., et al. Mitochondrial fission in apoptosis, neurodegeneration and aging. Current Opinion in Cell Biology, 2003; 15(6): 706-716. | |
| |
3. Camins A., Sureda F., Junyent F. et al. An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders. Expert Opin. Investig Drugs, 2010; 19(5): 587-604. | |
| |
4. Castedo M., Perfettini J.L., Roumier T. et al. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell Death. Differ, 2002; 9(12): 1287-1293. | |
| |
5. Cooper А., Gitler A., Cashikar A. α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models. Science, 2006; 313(57): 328-335. | |
| |
6. Copani A., Melchiorri D., Caricasole A. et al. Beta-amyloid-induced syntesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons. J. Neurosci, 2002; 22(10): 3963-3968. | |
| |
7. Currais A., Hortobagyi T., Soriano S. The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease. Aging, 2009; 1(4): 363-371. | |
| |
8. da Costa A.C, Checler F. Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism? Cell Signal, 2010; in print. | |
| |
9. De Zio D., Giunta L., Corvaro M., et al. Expanding roles of programmed cell death in mammalian neurodevelopment. Cell. Dev. Biol, 2005; 16(2): 281-294. | |
| |
10. Demir O., Singh S., Klimaschewski L. et al. From birth till death: neurogenesis, cell cycle, and neurodegeneration. Anat. Rec. (Hoboken), 2009; 292(12): 1953-1961. | |
| |
11. Dranovsky A., Vincent I., Gregor L. et al. Cdc2 hosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. Neurobiol. Aging, 2001; 22(4): 517-528. | |
| |
12. Driscoll M., Gerstbrein B. Dying for a cause: invertebrate genetics takes on human neurodegeneration. Nature Revievs, 2003; 4: 181-193. | |
| |
13. Edinger A., Thompson C. Death by design: apoptosis, necrosis and autophagy. Current Opinion in Cell Biology, 2004; 16(6): 663-669. | |
| |
14. Elmore S. Apoptosis: a Review of Programmed Cell Death. Toxicologic Pathology, 2007; 35: 495-516. | |
| |
15. Erol A. Are paradoxical cell cycle activities in neurons and glia related to the metabolic theory of Alzheimer's disease? J. Alzheimers Dis, 2010; 19(1): 129-135. | |
| |
16. Friedlander R. Apoptosis and Caspases in Neurodegenerative Diseases. Engl. J. Med, 2003; 348: 1365-1375. | |
| |
17. Gil G.M., Rego A.C. Mechanisms of neurodegeneration in Huntington's disease. Eur. J. Neurosci, 2008; 27: 2803-2820. | |
| |
18. Gulyaeva N.V. Cell cycle induction in postmitotic mature neurons and neurodegeneration: a basic for novel Therapeutic strategies in neurodegenerative disease? Нейрохимия, 2004; 21(3): 190-194. | |
| |
19. Haass C., De Strooper B. The presenilins in Alzheimer's disease - proteolysis holds the key. Science, 1999; 286: 916-919. | |
| |
20. Heng M.Y., Detloff P.J., Albin R.L. Rodent genetic models of Huntington disease. Neurobiol. Dis, 2008; 27: 11-18. | |
| |
21. Hernandez-Ortega K., Ferrera P., Arias C Sequential expression of cell cycle regulators and Alzheimer's disease related proteins in entorhinal cortex after hippocampal excitotoxic damage. J. Neurosci. Res, 2007; 85(8): 1744-1751. | |
| |
22. Herrup K., Busser J.C. The induction of multiple cell cycle events precedes target-related neuronal death. Development, 1995; 121(8): 2385-2395. | |
| |
23. Hom R.K, Bowers S., Sealy J.M., et al. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg. Med. Chem. Lett, 2010; 20(24): 7303-7307. | |
| |
24. Husseman J.W., Nochlin D., Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative disease. Neurobiol. Aging, 2000; 21(6): 815-828. | |
| |
25. Ishimura R., Martin G.R., Ackerman S.L. Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J. Neurosci, 2008; 28: 4938-4948. | |
| |
26. Konishi Y., Lehtinen M., Donovan N. et al. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol. Cell, 2002; 9(5): 1005-1016. | |
| |
27. Lin S., Chong Z.Z., Maiese K. Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat. Neurosci. Lett, 2001; 310(2-3): 173-177. | |
| |
28. Lukiw W.J, Bazan N.G. Survival signalling in Alzheimer's disease. Biochem. Soc. Trans, 2006; 34: 1277-1282. | |
| |
29. Martin L.J., Liu Z., Chen K. et al. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J. Comp. Neurol, 2007; 500: 20-46. | |
| |
30. Mattson S., Scotte M., Garier S. et al. Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs.normal rats. Apoptosis, 2000; 5(2): 173-179. | |
| |
31. Miller M.W., Peter A., Wharton S.B., et al. Proliferation and death of conditionally immortalized neural cells from murine neocortex: p53 alters the ability of neuron-like cells to re-enter the cell cycle. Brain Res, 2003; 7: 57-66. | |
| |
32. Nguyen M.D., Boudreau M., Kriz J. et al. Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutasel. J. Neurosci, 2003; 23(6): 2131-2140. | |
| |
33. Nunomura A., Moreira P.I., Lee H.G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neuronal Disorder Drug. Targets, 2007; 6: 411-423. | |
| |
34. Pasinelli P., Brown R.H. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat. Rev. Neurosci, 2006; 7: 710-723. | |
| |
35. Pérez-Martínez D.A. The role of lithium in neurodegenerative diseases: new registries for old actors. Neurologia, 2009; 24(3): 143146. | |
| |
36. Ranganathan S., Bowser R. Alterations in G-1 to S-phase cell cycle regulators during amyotrophic lateral sclerosis. Am. J. Pathol, 2003; 162(3): 823-835. | |
| |
37. Rigamonti D., Bauer J.H., De-Fraja C. et al. Wild-type huntingtin protects from apoptosis upstream of caspase-3. J.Neurosci, 2000; 20: 3705-13. | |
| |
38. Robert M., Friedlander M.D. Apoptosis and caspases in neurodegenerative disease. N. Engl. Med, 2003; 348: 1365-1375. | |
| |
39. Suzuki T. Molecular cloning of a novel apoptosis-related gene human Nap1 (NCKAP1) and its possible relation to Alzheimer disease. Genomics, 2000; 63: 246-254. | |
| |
40. Ueberham U., Hessel A., Arendt T. Cyclin C expression is involved in the pathogenesis of Alzheimer's disease. Neurobiol. Aging, 2003; 24: 427-435. | |
| |
41. Viana R., Fonseca M., Ramalho R. et al. Organelle stress sensors and cell death mechanisms in neurodegenerative diseases. CNS Neuronal Disorder Drug/ Targets, 2010; 9(6): 679-692. | |
| |
42. Vincent I., Rosado M., Davies P. Mitotic mechanisms in Alzheimer's disease? J. Cell Biol, 1996; 132(3): 413-425. | |
| |
43. Walsh E.P., Brown N.H. A screen to identify Drosophila genes required to integrin-mediated adhesion. Genetics, 1998; 150(2): 791-05. | |
| |
44. Wang X. The anti-apoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci. Ther, 2009; 15(4): 345-7. | |
| |
45. Whitworth A., Wes P., Pallanck L. Drosophila models pioneer a new approach to drug discovery for Parkinson's disease. Drug. Discov. Today, 2006; 11: 119-126. | |
| |
46. Yang Y., Mufson E.J., Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci, 2003; 23(7): 2557-2563. | |
| |
47. Zhivotovsky B, Orrenius S. Cell cycle and cell death in disease: past, present and future. J. Intern Med, 2010; 268(5): 395-409. | |
| |
48. Zhu X., Mc Shea A., Peggy L.R. et al. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP1 associated regulator of cyclin B, in Alzheimer's disease. J. Neurosci. Res, 2004; 75(5): 698-703. | |
| |
49. Zhu X., Siedlak SL., Wang Y. et al. Neuronal binucleation in Alzheimer disease hippocampus. Neurobiol, 2008; 34(4): 457-465. |
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