SOME BLOOD BIOCHEMICAL INDICES OF MICE WITH pttg GENE KNOCKOUT
DOI: http://dx.doi.org/10.30970/sbi.0503.178
Abstract
Liver injury of any etiology is accompanied by increased fibrogenesis. One of the key genes that may influence in the development of liver fibrosis, is pttg gene (Pituitary tumor transforming gene). This gene encodes a protein seсurin which plays an important role in the maintenance of sister chromatids in associated state in S-phase cell cycle. This pttg gene involved in regulation of such key events, as mitosis, reparation DNA, and apoptosis. The effect of pttg gene knockout on some biochemical parameters of blood serum of mice that can be serological markers of liver functional state, namely the activity of alanineaminotransferase, aspartateaminotransferase and lactate dehydrogenase, serum albumin concentration, total and direct bilirubin in blood serum of wild-type mice and mice with pttg gene knockout in different age groups of these animal.
Keywords
Full Text:
PDF (Українська)References
1. Бабак О.Я., Колесникова Е.В., Кравченко Н.А. Фиброз печени: современные представления о механизмах, способах диагностики и лечения. Сучасна гастроентерологія, 2009; 2: 5 -17. | |
| |
2. Камышников В.С. Клинико-биохимическая лабораторная диагностика. Справочник: В 2-х т. Москва: Интерпрессервис, 2003. Т. 1. 495 с. | |
| |
3. Лабораторные методы исследования в клинике. Под ред. В. В. Меньшикова. Москва: Медицина, 1987. 365 с. | |
| |
4. Уикли Б. Электронная микроскопия. Москва, 1975. 324 с. | |
| |
5. Afdhal N.H., Nunes D. Evaluation of liver fibrosis: A concise review. Am. J. Gastroenterol, 2004; 27: 1704-1713. | |
| |
6. Balsano C., Alisi A.V. Liver fibrosis and therapeutic strategies: the goal for improving metabolism. Curr. Drug. Targets, 2009; 10(6): 505-512. | |
| |
7. Bataller R., Brenner D.A. Liver fibrosis. J. Clin. Invest, 2005;115: 209-218. | |
| |
8. Calеs P., Lainе F., Boursier J. et al. Comparison of blood tests for liver fibrosis specific or not to NAFLD. J. of Hepatol, 2007; 50: 165-17. | |
| |
9. Davern T.J., Scharschmidt B.F. Biochemical liver tests. Feldman M., ed. Gastrointestinal and Liver Disease. V. 2. 7th ed. Philadelphia: W. B. Saunders, 2002.1227-1239. | |
| |
10. De Ledinghen V., Le Bail B., Rebouissoux L. et al. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy. J. Pediatr. Gastroentorol. Nutr, 2007; 45: 443-450. | |
| |
11. Gianni E., Risso D., Botta F. et al. Validity and clinical utility of the aspartate aminiransferase_alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus_related chronic liver disease. Arch. Intern. Med, 2003; 163: 218-224. | |
| |
12. Kim D.S., Franklyn J.A., Boelaert K. et al. Pituitary tumor transforming gene (pttg) stimulates thyroid cell proliferation via a vascular endothelial growth factor /kinase insert domain receptor/ inhibitor of DNA binding-3 autocrine pathway. J. of Clin. Endocrinol. and Metabolism, 2006; 91: 4603-4611. | |
| |
13. Laine F., Bendavid C., Moirand R. et al. Prediction of liver fibrosis in patients with features of the metabolic syndrome regardless of alcohol consumption. Hepatology, 2004; 39: 1639-1646. | |
| |
14. Lee U.E., Ghiassi-Nejad Z., Paris A.J. et al. Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. FEBS Lett, 2010; 584(5) :1006-10. | |
| |
15. Pei L., Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (pttg). Molecular Endocrinol, 1997; 11: 433-441. | |
| |
16. Pratt D.S., Kaplan M.M. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N. Engl. J. Med, 2000;3 42(17): 1266-1271. | |
| |
17. Rajamannan N.M., Subramaniam M., Abraham T.P. et al. TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy: discovery and characterization of a novel signaling pathway. J. of Cell. Biochemistry, 2007; 100: 315-325. | |
| |
18. Salehi F., Kovacs K., Scheithauer B.W. et al. Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update. Endocrine-Related Cancer, 2008; 15(3): 721-743. | |
| |
19. Stoika R., Melmed S. Expression and function of pituitary tumour transforming gene for T-lymphocyte activation. Brit. J. of Haematology, 2002; 119: 1070-1074. | |
| |
20. Zou H., McGarry TJ., Bernal T., Kirschner M.W. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science, 1999; 285: 418-422. | |
Refbacks
- There are currently no refbacks.
Copyright (c) 2011 Studia biologica
This work is licensed under a Creative Commons Attribution 4.0 International License.