O. P. Kanyuka, Ye. Z. Filyak, S. V. Afanasyev, N. O. Sybirna



Liver injury of any etiology is accompanied by increased fibrogenesis. One of the key genes that may influence in the development of liver fibrosis, is pttg gene (Pituitary tumor transforming gene). This gene encodes a protein seсurin which plays an important role in the maintenance of sister chromatids in associated state in S-phase cell cycle. This pttg gene involved in regulation of such key events, as mitosis, reparation DNA, and apoptosis. The effect of pttg gene knockout on some bioche­mical parameters of blood serum of mice that can be serological markers of liver functional state, namely the activity of alanineaminotransferase, aspartateaminotransferase and lactate dehydrogenase, serum albumin concentration, total and direct bilirubin in blood serum of wild-type mice and mice with pttg gene knockout in different age groups of these animal.


gene pttg, liver, fibrosis, bilirubin, lactate dehydrogenase


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