EFFECT OF LACK OF pttg-1 ON DEVELOPMENT OF AUTOIMMUNE PROCESSES
DOI: http://dx.doi.org/10.30970/sbi.0502.146
Abstract
PTTG (Pituitary Tumour Transforming gene-1) is a protoncogene which is expressed in testes, thick and thin bowel, and in activated lymphocytes. Protein product of this gene is involved in mitosis and cell cycle regulation. Lack of pttg in mice (pttg-КО) leads to thymic hyperplasia and splenic hypoplasia. Specific aim of this work was to investigate presence of anti-dsDNA, anti-core histons antibodies and also check affinity of producated antibodies of wild type mice and mice wit lack of pttg-1. The level of antibodies to single strand, double strand DNA and core histons of wild type and mice lacking pttg were investigated. Affinity of autoantibodies to double strand native DNA was studied. The revealed changes of autoantibodies level to double strand DNA and core histones suggest that the lack of pttg-1 causes the development of autoimmune processes.
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