INFLUENCE OF LONG-TERM INJECTION OF CdCl2 ON THE ACTIVITY OF LEUCOPOIESIS PROCESSES IN RATS

L. P. Biletska


DOI: http://dx.doi.org/10.30970/sbi.0602.205

Abstract


It was shown that long-term (7 and 21 day) administration of CdCl2 (3 mg/kg) increases the number of white blood cells in rats appropriately for 57.3% and 38.5%, these changes we are mediated by 54.7% increase of the content of polymorphonuclear granulocytes. Analysis of the dynamics of cells of leukopoiesis system under the influence of CdCl2 indicates that decreased monocytes content results in a decrease of number of agranulocytes in rats’ blood. Thus, in animals, exposed to long-term influence of CdCl2,the stage of antigen presentation might occur less effective due to a diminished number of macrophages. Such effect, together with a decrease of leukocytes content, could impair the immune defense in treated animals.


Keywords


leukocytes, cadmium, neutrophilic granulocytes

References


1. Грузєва О.В. Стан забруднення довкілля в країнах Европи та Україні. Укр. наук.-мед. молодіжн. журнал, 2007; (1-2): 36-40.

2. Kудрявцев А.А., Кудрявцева Л.А., Привольнев Т.И. Гематология животных и рыб. М.: Колос, 1969. 240 с.

3. Boyum A.A. A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. Scand. J. Clin. Lab. Invest, 1968; 21(97): 51-76.

4. Holvoet P. Endothelial dysfunction, oxidation of low-density lipoprotein, and cardiovascular disease. Ther. Apher, 1999; 3: 287-293.
https://doi.org/10.1046/j.1526-0968.1999.00169.x
PMid:10608719

5. Liu J., Qu W., Kadiiska M.B. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol. Appl. Pharmacol, 2009; 238(3): 209-214.
https://doi.org/10.1016/j.taap.2009.01.029
PMid:19236887 PMCid:PMC4287357

6. Li Y.S., Hayakawa K., Hardy R.R. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med, 1993; 178(3): 951-960.
https://doi.org/10.1084/jem.178.3.951
PMid:8350062

7. Min K.S., Ueda H., Tanaka K. Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet. Toxicol. Lett, 2008; 176(1): 85-92.
https://doi.org/10.1016/j.toxlet.2007.10.011
PMid:18054826

8. Mishell B.B., Shiigi S.M. Selected Methods in Cellular Immunology. W.H. Freeman and Company, San Francisco, 1980: 486 p.

9. O'Flaherty E.J. Physiologically based models for bone-seeking elements. IV. Kinetics of lead disposition in humans. Toxicol. App. Pharmacol, 1991; 118: 16-29.
https://doi.org/10.1006/taap.1993.1004
PMid:8430422

10. Thompson J., Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod. Toxicol, 2008; 25(3): 304-315.
https://doi.org/10.1016/j.reprotox.2008.02.001
PMid:18367374


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