Ca 2+  RELEASING PROCESS AND NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE

S. Bychkova

doi:10.30970/sbi.0702.282

Ca²⁺RELEASING PROCESS AND NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE

S. Bychkova

DOI: http://dx.doi.org/10.30970/sbi.0702.282

Abstract

The paper is devoted to recognizing of nicotinic acid adenine dinucleotide phosphate (NAADP) as releaser of intracellular calcium from intracellular stores. It was revealed the current concepts of the mechanisms of NAADP synthesis inside the cell resuming involve enzyme CD38. The effect of NAADP was described in several cells and tissue preparation, as well as in sea urchin eggs. Briefly, it was characterized the acidic store of cells, that is sensitive to NAADP as it had been shown by different authors. Assumed mechanisms of Ca²⁺ accumulating in acidic store predict involve proton gradient across membrane of acidic store. The channels structure of acidic store and endoplasmatic reticulum are considered as receptors to NAADP. Potential mechanisms for NAADP-induced calcium release was considered: direct model, trigger Ca²⁺-induced Ca²⁺-releasing model, promiscuous coupling model, conformational coupling model and also unifying hypothesis, that explains the differences between other mechanisms. Physiological processes in which NAADP is involved are described.

Keywords

NAADP, acidic store, Ca2+, ryanodine receptor, two-pore channels

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References

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