CИНТЕЗ І АНТИПРОЛІФЕРАТИВНА АКТИВНІСТЬ 3-АРИЛ-5-{[(1- АРИЛ-1Н-ТЕТРАЗОЛ-5-ІЛ)ТІО]МЕТИЛ}-1,2,4-ОКСАДІАЗОЛІВ

M. Tupychak, N. Pokhodylo

Анотація


Синтезовано чимало нових 3-арил-5-{[(1-арил-1Н-тетразол-5-іл)тіо]метил}-1,2,4-оксадіазолів та досліджено їх антипроліферативну активність на 60 лініях ракових клітин. Вибрані сполуки проявили невисоку активність, що свідчить про необхідність їх значної хімічної модифікації задля відкриття активних агентів.

 

Ключові слова: тетразоли, 1,2,4-оксадіазоли, антипроліферативна активність, рак.


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DOI: http://dx.doi.org/10.30970/vch.6301.245

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