ВПЛИВ КВЕРЦЕТИНУ НА ВМІСТ МЕТИЛГЛІОКСАЛЮ У ЩУРІВ З ЕКСПЕРИМЕНТАЛЬНОЮ ІНСУЛІНОРЕЗИСТЕНТНІСТЮ

Анотація

Methylglyoxal (MG) is a highly reactive dicarbonyl and precursor to free radicals and advanced glycation endproducts that contribute to diabetes and its complications. Fructose feeding for 8 weeks caused hyperglycemia and hyperinsulinemia, induced serum and liver MG accumulation and JNK phosphorylation in the liver. Quercetin treatment attenuated the insulin resistance status by decreasing MG, glucose, insulin levels in the serum and inhibition JNK.