ДОСЛІДЖЕННЯ АПОПТОЗУ ЕНТЕНРОЦИТІВ ПРИ ХРОНІЧНОМУ КАРАГІНАН-ІНДУКОВАНОМУ ГАСТРОЕНТЕРОКОЛІТІ МЕТОДОМ ФЛУОРЕСЦЕНТНИХ ЗОНДІВ

Анотація

A study of the lipid bilayer of membranes of enterocytes of rats with chronic gastroenterocolitis was performed in this work. For the study, we used fluorescent probes - ortho-hydroxy derivatives of oxazole, molecules of which bind non-covalently to the membranes of cells and respond to changes in the microenvironment. It was found that during the course of chronic carrageenan-induced gastroenterocolitis an increase in hydration of the polar regions of enterocyte membranes occurs. The increase in hydration is attributed to the activation of the apoptosis of enterocytes. It is shown that a fluorescent probe (2-(2´-OH-phenyl) -5-phenyl-1,3-oxazole) can be used for the detection of apoptosis of enterocytes.