СИНТЕТИЧНІ ПІДХОДИ ДО ОДЕРЖАННЯ ГЕТЕРИЛЗАМІЩЕНИХ 1,3,4-ТІАДІАЗОЛІВ ЯК БІОЛОГІЧНО АКТИВНИХ СПОЛУК

M. Lelyukh, B. Zimenkovsky, I. Chaban, L. Shelepeten, V. Matiychuk

Анотація


На основі проведеного літературного огляду систематизовано дані про методи одержання, можливі напрями хімічної модифікації та фармакологічну активність гетероциклічних систем на основі 1,3,4-тіадіазолу. З’ясовано, що зазначений скафолд як основний структурний компонент наявний у низці категорій лікарських засобів, а також відомих антимікробних, протизапальних, анальгетичних, протипухлинних, проти-туберкульозних та противірусних агентів. Така суттєва та різностороння активність похідних тіадіазолу допомагає розглядати наведений каркас як фармакологічно значущий, що підтверджує його значення та універсальність у медичній хімії.

 

Ключові слова: синтез, 1,3,4-тіадіазоли, хімічна модифікація, біологічна активність.


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DOI: http://dx.doi.org/10.30970/vch.5902.254

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